INT195099

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 5.31
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (F2r) plasma membrane (F2r) signal transducer activity (F2r)
Anatomy Link Frequency
neurons 4
brain 4
astrocytes 2
F2r (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 161 97.92 Very High Very High Very High
Nerve growth factor 56 94.96 High High
Inflammation 66 93.44 High High
Pain 12 90.80 High High
cva 7 88.28 High High
cytokine 63 78.40 Quite High
imagery 21 67.60 Quite High
Inflammatory mediators 27 60.80 Quite High
nociceptor 32 46.16 Quite Low
qutenza 28 37.68 Quite Low
Disease Link Frequency Relevance Heat
Penetrating Head Injuries 35 99.76 Very High Very High Very High
Brain Injury 70 99.72 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 7 99.12 Very High Very High Very High
Viral Meningitis 7 98.96 Very High Very High Very High
Injury 391 98.76 Very High Very High Very High
Nociception 42 93.80 High High
INFLAMMATION 96 93.44 High High
Hypertrophy 21 90.96 High High
Pain 12 90.80 High High
Cv General 3 Under Development 7 88.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine which cell type is induced to express PAR-1, the effects of IL-1?
Positive_regulation (induced) of Gene_expression (express) of PAR-1
1) Confidence 0.57 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.69 Pain Relevance 0.07
The PAR-1 expression was dramatically increased in the WT mice at 3 days post injury (Fig. 3).
Positive_regulation (increased) of Gene_expression (expression) of PAR-1 associated with injury
2) Confidence 0.57 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.85 Pain Relevance 0.09
A recent report documents upregulated PAR-1 expression in astrocytes during HIV encephalitis [58].
Positive_regulation (upregulated) of Gene_expression (expression) of PAR-1 in astrocytes associated with acquired immune deficiency syndrome or hiv infection and viral meningitis
3) Confidence 0.57 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.74 Pain Relevance 0.08
Altogether, these results suggest that brain cells are not responsible for the induction of PAR-1 expression after traumatic brain injury.
Positive_regulation (induction) of Gene_expression (expression) of PAR-1 in brain associated with brain injury
4) Confidence 0.57 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.67 Pain Relevance 0.03
The level of PAR-1 protein expression after IL-1?
Positive_regulation (after) of Gene_expression (expression) of PAR-1 protein
5) Confidence 0.41 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.67 Pain Relevance 0.07
The induced levels of the protease-activated receptor, PAR-1, were significantly attenuated in IL-1R1-null mice.
Positive_regulation (induced) of Gene_expression (levels) of PAR-1
6) Confidence 0.41 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.90 Pain Relevance 0.17
Therefore, we performed in vitro studies to examine which brain cell increases PAR-1 expression in response to IL-1?
Spec (examine) Positive_regulation (increases) of Gene_expression (expression) of PAR-1 in brain
7) Confidence 0.38 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.53 Pain Relevance 0.07
The increase in responsiveness was seen as an increase in the number of neurons expressing functional PAR1/4 receptors in response to a maximal dose of thrombin, suggesting the de novo appearance of functional receptors in neurons that previously did not express them, rather than sensitization of existing receptors.
Positive_regulation (increase) of Gene_expression (expressing) of PAR1 in neurons
8) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.26 Pain Relevance 0.20
To test this more conclusively it would be desirable to activate PAR3 alone, but specific activation of PAR3 in neurons coexpressing PAR1 and PAR4 is not possible because PAR3 peptides also activate PAR1 and PAR4 [45,46].
Positive_regulation (activation) of Gene_expression (coexpressing) of PAR1 in neurons
9) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0

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