INT1951

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1978
Last Reported 2011
Negated 8
Speculated 3
Reported most in Body
Documents 345
Total Number 348
Disease Relevance 176.99
Pain Relevance 62.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
microglia 21
macrophages 18
monocyte 10
lung 8
epithelial cells 7
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 211 100.00 Very High Very High Very High
Inflammatory stimuli 120 100.00 Very High Very High Very High
spastic colon 114 100.00 Very High Very High Very High
Inflammation 6346 99.98 Very High Very High Very High
chemokine 799 99.92 Very High Very High Very High
Eae 75 99.82 Very High Very High Very High
rheumatoid arthritis 447 99.80 Very High Very High Very High
local anesthetic 12 99.76 Very High Very High Very High
Inflammatory response 921 99.72 Very High Very High Very High
Spinal cord 58 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 2225 100.00 Very High Very High Very High
Sprains And Strains 686 100.00 Very High Very High Very High
Chlamydia Infection 236 100.00 Very High Very High Very High
Francisella Infection 169 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

111 100.00 Very High Very High Very High
Uveitis 87 100.00 Very High Very High Very High
Pseudomonas Infection 48 100.00 Very High Very High Very High
INFLAMMATION 7282 99.98 Very High Very High Very High
Disease 2572 99.96 Very High Very High Very High
Cirrhosis 153 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gene expression profiling reveals upregulation of Tlr4 receptors in Cckb receptor deficient mice.
Positive_regulation (upregulation) of Tlr4
1) Confidence 0.70 Published 2008 Journal Behav. Brain Res. Section Title Doc Link 18054398 Disease Relevance 0.83 Pain Relevance 0.68
In addition, we found significant elevation of the Toll-like receptor 4 (Tlr4) in the supraspinal structures of the mice with deleted Cckbr compared to wt control mice.
Positive_regulation (elevation) of Toll-like receptor 4
2) Confidence 0.70 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18054398 Disease Relevance 0.78 Pain Relevance 0.70
In addition, we found significant elevation of the Toll-like receptor 4 (Tlr4) in the supraspinal structures of the mice with deleted Cckbr compared to wt control mice.
Positive_regulation (elevation) of Tlr4
3) Confidence 0.70 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18054398 Disease Relevance 0.78 Pain Relevance 0.70
All in all, our data imply that oral supplement of certain flora to activate TLR4 in intestinal mucosa but not overload the intestinal flora could be a new therapeutic strategy to enhance systemic innate immunity in major burn patients.
Neg (not) Positive_regulation (activate) of TLR4 associated with burns
4) Confidence 0.69 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 0.84 Pain Relevance 0.03
Importantly, the endogenous ligands that can activate TLR2 and TLR4 are strongly upregulated in these TECs upon I/R injury [15].
Positive_regulation (activate) of TLR4 in TECs associated with injury
5) Confidence 0.69 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570789 Disease Relevance 0.64 Pain Relevance 0.09
Activation of TLR4 induces production of the pro-inflammatory cytokines TNF, IL-1?
Positive_regulation (Activation) of TLR4 associated with inflammation and cytokine
6) Confidence 0.68 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1933437 Disease Relevance 0.82 Pain Relevance 0.30
The increase in local TLR4 levels in the culprit coronary artery in patients with AMI is a novel and unexpected finding.
Positive_regulation (increase) of TLR4 in coronary artery
7) Confidence 0.67 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.92 Pain Relevance 0.05
Our results revealed increased TLR-4 mRNA levels..
Positive_regulation (increased) of TLR-4 mRNA
8) Confidence 0.67 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2984476 Disease Relevance 0.84 Pain Relevance 0.30
As expected, a marked increase in TLR-4 mRNA was observed after feeding WD in sham mice (Figure 4).
Positive_regulation (increase) of TLR-4 mRNA
9) Confidence 0.67 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2984476 Disease Relevance 0.37 Pain Relevance 0.22
Although we did not specifically measure TLR3 expression in the current study, review of our previously published microarray study indicates that TLR4 mRNA but not TLR3 mRNA is increased in mice mechanically ventilated with a tidal volume of 10 mL/kg as compared with control mice [9].
Positive_regulation (increased) of TLR4
10) Confidence 0.62 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.30 Pain Relevance 0.09
It is concluded that the drug induced inhibition of LPS activation was due solely to the toxicity of the compounds.
Positive_regulation (activation) of LPS associated with toxicity
11) Confidence 0.61 Published 1978 Journal Scand. J. Immunol. Section Abstract Doc Link 306664 Disease Relevance 0.17 Pain Relevance 0.08
These data demonstrate that lignocaine has significant inhibitory effects on the activation of TLR-4, NF-kappaB and MAPKs in activated macrophages.
Positive_regulation (activation) of TLR-4 in macrophages
12) Confidence 0.60 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18505446 Disease Relevance 0 Pain Relevance 0.26
Any compound able at increasing this natural soluble TLR4 would thus be of potential interest in treating patients with sepsis.
Positive_regulation (increasing) of TLR4 associated with sepsis
13) Confidence 0.60 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.36 Pain Relevance 0.15
This gene encodes a receptor required for activation of TLR4 by endotoxin.
Positive_regulation (activation) of TLR4
14) Confidence 0.58 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440793 Disease Relevance 0.35 Pain Relevance 0
However, another protein, CD14 is critical to LPS activation of TLR-4.
Positive_regulation (activation) of TLR-4
15) Confidence 0.56 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC527876 Disease Relevance 0.29 Pain Relevance 0.26
Our previous studies suggest that 12/15LO oxidation products activate toll-like receptor-4 (TLR4) in macrophages [18], [19].
Positive_regulation (activate) of TLR4 in macrophages
16) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 0.58 Pain Relevance 0.07
Our previous studies suggest that 12/15LO oxidation products activate toll-like receptor-4 (TLR4) in macrophages [18], [19].
Positive_regulation (activate) of toll-like receptor-4 in macrophages
17) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 0.58 Pain Relevance 0.07
In contrast, in a model of aortic constriction in rats, activation of TLR4 signalling reduced the hypertrophy response, an effect that was reversed through administrating a TLR4 antagonist [73].
Positive_regulation (activation) of TLR4 associated with hypertrophy and antagonist
18) Confidence 0.51 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 1.04 Pain Relevance 0.22
The TLR4 activation was highest in patients with acute heart failure [59].
Positive_regulation (activation) of TLR4 in heart associated with myocardial infarction
19) Confidence 0.51 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.56 Pain Relevance 0.10
Indeed, real time PCR analysis detected a CCI-induced upregulation of Tlr4 and Il1b expression in the lumbar region of wt but not Cckbr KO mice.
Positive_regulation (upregulation) of Tlr4 in lumbar region associated with eae and lumbar region
20) Confidence 0.50 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18054398 Disease Relevance 0.70 Pain Relevance 0.66

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox