INT195101

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.02
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
extracellular matrix 2
Gfap (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 23 95.40 Very High Very High Very High
Inflammatory mediators 3 69.08 Quite High
cytokine 9 63.60 Quite High
cva 1 63.36 Quite High
Inflammation 6 5.00 Very Low Very Low Very Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 3 99.62 Very High Very High Very High
Penetrating Head Injuries 5 97.72 Very High Very High Very High
Injury 55 86.84 High High
Brain Injury 10 70.20 Quite High
INFLAMMATION 10 68.68 Quite High
Cv General 3 Under Development 1 63.36 Quite High
Disease 4 56.68 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 34.40 Quite Low
Viral Meningitis 1 34.08 Quite Low
Stab Wounds 15 19.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, this study on the effect of a penetrating brain injury in mice lacking IL-1R1 demonstrates that IL-1R1 deletion results in: 1) attenuated hypertrophy of astrocytes; 2) delayed cellular GFAP induction; 3) diminished induction of PAR1; 4) intact induction of extracellular matrix proteins and 5) intact induction of glutamate transporters, glutamine synthetase and S-100B.
Negative_regulation (delayed) of Positive_regulation (induction) of GFAP in extracellular matrix associated with hypertrophy, glutamate and penetrating head injuries
1) Confidence 0.31 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 1.02 Pain Relevance 0.18

General Comments

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