INT195103

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Context Info
Confidence 0.66
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 3.00
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc1a2) plasma membrane (Slc1a2)
Anatomy Link Frequency
whisker 6
neuronal 4
brain 2
astrocytes 2
Slc1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 322 100.00 Very High Very High Very High
primary somatosensory cortex 5 98.16 Very High Very High Very High
Somatosensory cortex 15 95.28 Very High Very High Very High
excitatory amino acid 5 94.32 High High
long-term potentiation 5 83.24 Quite High
Hippocampus 10 81.60 Quite High
Nerve growth factor 16 72.48 Quite High
cerebral cortex 10 61.04 Quite High
anesthesia 14 37.28 Quite Low
Inflammatory mediators 12 24.88 Low Low
Disease Link Frequency Relevance Heat
Injury 225 99.98 Very High Very High Very High
Penetrating Head Injuries 20 99.98 Very High Very High Very High
Stab Wounds 60 99.84 Very High Very High Very High
Hypoxia 4 85.20 High High
Anxiety Disorder 5 84.24 Quite High
Brain Injury 40 82.20 Quite High
Death 12 78.84 Quite High
Disease 16 77.52 Quite High
Epilepsy 10 73.16 Quite High
Generalized Anxiety Disorder 5 60.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using Western blot analysis on single barrel columns corresponding to the stimulated whisker, we found that expression levels of GLT1 and GLAST were significantly increased.
Positive_regulation (increased) of Gene_expression (expression) of GLT1 in whisker
1) Confidence 0.66 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0.15 Pain Relevance 0.28
Western blot analysis (Figure 1C and 1D) shows that after 24 h of whisker stimulation, GLAST and GLT1 expression increased 2.46-fold and 2.65-fold of the unstimulated value (GLAST: 246 ± 20.9% mean ± standard deviation [SD]; GLT1: 265 ± 38.1%; p < 0.01, Tukey honestly significant difference [HSD]).
Positive_regulation (increased) of Gene_expression (expression) of GLT1 in whisker
2) Confidence 0.47 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0 Pain Relevance 0.07
On a longer time scale, however, the expression levels of GLT1 and GLAST have been shown, in vitro, to depend on the level of neuronal activity [14].
Positive_regulation (depend) of Gene_expression (levels) of GLT1 in neuronal
3) Confidence 0.44 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0.08 Pain Relevance 0.36
Using Western blot analysis on single barrel columns corresponding to the stimulated whisker, we found that expression levels of GLT1 and GLAST were significantly increased.
Positive_regulation (increased) of Gene_expression (levels) of GLT1 in whisker
4) Confidence 0.44 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0.15 Pain Relevance 0.28
This study shows that an increase in sensory activity increases the expression of the astrocytic glutamate transporters GLT1 and GLAST in the corresponding region of the primary somatosensory cortex, without affecting the neuronal glutamate transporter EAAC1.
Positive_regulation (increases) of Gene_expression (expression) of GLT1 in neuronal associated with primary somatosensory cortex and glutamate
5) Confidence 0.38 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0.06 Pain Relevance 0.19
Thus, a neocortical stab wound injury induces the expression of GLT-1, GLAST, the GS, and S-100B, but our data indicate that this induction is independent of IL-1R1.
Positive_regulation (induces) of Gene_expression (expression) of GLT-1 associated with injury and stab wounds
6) Confidence 0.35 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.80 Pain Relevance 0.15
Our results show that in both WT and receptor-null mice, stab wound injury increased GLAST, GLT-1, GS and S-100B protein expression at 3 day post injury by 8, 6, 4 and 12 fold, respectively (Fig. 7).
Positive_regulation (increased) of Gene_expression (expression) of GLT-1 associated with injury and stab wounds
7) Confidence 0.35 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.49 Pain Relevance 0.28
Similarly, GLT-1 and GLAST mRNA expression are induced after cultured astrocytes are physically traumatized [77,78].
Positive_regulation (induced) of Gene_expression (expression) of GLT-1 in astrocytes
8) Confidence 0.35 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.70 Pain Relevance 0.23
Here we demonstrate that a penetrating brain injury increases the expression of GLT-1 and GLAST.
Positive_regulation (increases) of Gene_expression (expression) of GLT-1 in brain associated with penetrating head injuries
9) Confidence 0.35 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.56 Pain Relevance 0.27

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