INT195104

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.18
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Il1r1) intracellular (Il1r1) protein complex (Il1r1)
signal transducer activity (Il1r1)
Anatomy Link Frequency
bladder 1
Il1r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 58 100.00 Very High Very High Very High
Glutamate 47 90.48 High High
substance P 22 68.32 Quite High
Pain 2 50.08 Quite High
cytokine 42 49.80 Quite Low
antagonist 8 48.68 Quite Low
interstitial cystitis 2 43.20 Quite Low
Central nervous system 25 42.32 Quite Low
nud 1 35.28 Quite Low
Nerve growth factor 9 30.96 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 75 100.00 Very High Very High Very High
Cancer 8 99.40 Very High Very High Very High
Hypoxia 5 99.24 Very High Very High Very High
Necrosis 3 99.16 Very High Very High Very High
Brain Injury 21 95.12 Very High Very High Very High
Injury 112 90.32 High High
Stab Wounds 30 87.60 High High
Penetrating Head Injuries 10 80.72 Quite High
Death 10 59.60 Quite High
Cicatrix 12 52.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several astrocytic functions are also independent of IL-1R1 (Fig. 7)
Neg (independent) Positive_regulation (independent) of IL-1R1
1) Confidence 0.40 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.67 Pain Relevance 0.21
Studies from our lab indicate that there is a dramatic induction of GLAST protein in WT and IL-1R1-null mice after a mild hypoxic/ischemic insult (Sen et al. unpublished observation).
Positive_regulation (induction) of IL-1R1-null associated with hypoxia
2) Confidence 0.18 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.82 Pain Relevance 0.21
In the presence of NK1R, Nkx2-5 _01 was significantly correlated with 36 transcripts which included several candidates for mediating bladder development (FGF) and inflammation (PAR-3, IL-1R, IL-6, ?
Positive_regulation (mediating) of IL-1R in bladder associated with inflammation
3) Confidence 0.02 Published 2007 Journal BMC Urol Section Abstract Doc Link PMC1888709 Disease Relevance 0.49 Pain Relevance 0.27
This event allows activation of the IL-1R-associated kinase (IRAK)/tumor necrosis factor receptor-associated factor 6 (TRAF6) pathway leading to nuclear translocation of the nuclear factor kappa beta (NF-?
Positive_regulation (activation) of IL-1R-associated associated with necrosis and cancer
4) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.20 Pain Relevance 0

General Comments

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