INT195105

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.41
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (F2r) plasma membrane (F2r) signal transducer activity (F2r)
Anatomy Link Frequency
urothelial cells 2
F2r (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 74 98.52 Very High Very High Very High
Glutamate 23 97.60 Very High Very High Very High
Nerve growth factor 18 94.64 High High
Calcitonin gene-related peptide 20 87.52 High High
cva 1 84.40 Quite High
Inflammatory response 12 82.16 Quite High
agonist 16 79.24 Quite High
metalloproteinase 2 77.04 Quite High
neuropeptide release 2 62.24 Quite High
Neuropeptide 12 60.52 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 97 98.52 Very High Very High Very High
Hypertrophy 3 90.64 High High
Encephalitis 1 86.96 High High
Penetrating Head Injuries 5 86.84 High High
Cv General 3 Under Development 1 84.40 Quite High
Brain Injury 10 80.80 Quite High
Injury 63 78.24 Quite High
Vasculitis 1 74.44 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 55.44 Quite High
Viral Meningitis 1 55.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, following acute and chronic inflammation, probably because of the shedding of urothelial cells bearing PARs, both PAR1 and PAR2 expression are reduced [24].
Negative_regulation (reduced) of Gene_expression (expression) of PAR1 in urothelial cells associated with inflammation
1) Confidence 0.37 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.51 Pain Relevance 0.28
The induced levels of the protease-activated receptor, PAR-1, were significantly attenuated in IL-1R1-null mice.
Negative_regulation (attenuated) of Gene_expression (levels) of PAR-1
2) Confidence 0.35 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.91 Pain Relevance 0.17
Fig. 8 examines the effect of exposure to neurotrophic factors on expression of functional PAR1/4 receptors, measured from PKC?
Negative_regulation (receptors) of Gene_expression (expression) of PAR1
3) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0.45

General Comments

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