INT195106

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.96
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cp) extracellular space (Cp) oxidoreductase activity (Cp)
extracellular region (Cp)
Anatomy Link Frequency
astrocytes 2
Cp (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 11 100.00 Very High Very High Very High
cytokine 18 88.96 High High
Nerve growth factor 4 80.16 Quite High
Inflammation 108 78.16 Quite High
Glutamate 23 60.64 Quite High
Central nervous system 46 24.80 Low Low
metalloproteinase 2 19.00 Low Low
COX2 1 16.84 Low Low
Inflammatory mediators 3 15.80 Low Low
dexamethasone 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 27 100.00 Very High Very High Very High
Pancreatitis 11 100.00 Very High Very High Very High
Injury 58 99.98 Very High Very High Very High
Carcinoma In Situ 1 99.32 Very High Very High Very High
Metastasis 41 91.00 High High
Pressure And Volume Under Development 1 85.84 High High
Pancreatic Cancer 22 83.48 Quite High
Stroke 2 83.44 Quite High
Repression 12 81.84 Quite High
INFLAMMATION 121 78.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cellular characterization of Cp: a candidate gene dependent on GR and LPS signaling
Positive_regulation (characterization) of Gene_expression (characterization) of Cp
1) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.15 Pain Relevance 0
The cellular characterization of Cp: a candidate gene dependent on GR and LPS signaling
Positive_regulation (on) of Gene_expression (characterization) of Cp
2) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.16 Pain Relevance 0
In addition, figure 6D shows that the four different probe sets used in the gene chip generated the same data, which all together provide very solid evidence that GR blockage is able to prevent LPS-induced Cp gene expression.
Positive_regulation (induced) of Gene_expression (expression) of Cp gene
3) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.21 Pain Relevance 0.04
In another study we demonstrated that the expression of ceruloplasmin (CP) is induced by a traumatic injury and that IL-1 is responsible for the injury-induced expression of CP in astrocytes [34].
Positive_regulation (induced) of Gene_expression (expression) of CP in astrocytes associated with injury
4) Confidence 0.16 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.92 Pain Relevance 0.25
Immunohistochemical analysis showed that ezrin was overexpressed in pancreatic ductal adenocarcinoma (PDAC) (91.4%) and precancerous lesions, i.e. the tubular complexes in chronic pancreatitis (CP) and pancreatic intraepithelial neoplasm (PanIN) (85.7% and 97.1%, respectively), compared to normal pancreatic tissues (0%).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CP associated with adenocarcinoma, carcinoma in situ and chronic pancreatitis
5) Confidence 0.12 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2916894 Disease Relevance 1.52 Pain Relevance 0.20

General Comments

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