INT195107

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Context Info
Confidence 0.51
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.63
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100b) extracellular region (S100b) nucleus (S100b)
cytoplasm (S100b)
Anatomy Link Frequency
glial cells 1
neurons 1
astrocytes 1
S100b (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 13 99.08 Very High Very High Very High
chemokine 1 98.08 Very High Very High Very High
Inflammation 22 87.76 High High
cytokine 25 67.76 Quite High
Glutamate 46 65.96 Quite High
cva 3 63.76 Quite High
Nerve growth factor 8 59.44 Quite High
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 121 99.56 Very High Very High Very High
Hypoxia 3 98.92 Very High Very High Very High
Stab Wounds 30 96.40 Very High Very High Very High
Cicatrix 14 91.12 High High
INFLAMMATION 30 87.76 High High
Alzheimer's Dementia 8 77.40 Quite High
Penetrating Head Injuries 10 68.60 Quite High
Disease 28 64.48 Quite High
Cv General 3 Under Development 3 63.76 Quite High
Brain Injury 49 60.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The S100B protein, abundant in glial cells of the CNS, predominately in astrocytes, belongs to a multigenic family of calcium-binding S100 proteins.
Localization (abundant) of S100B protein in astrocytes associated with central nervous system
1) Confidence 0.51 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2442079 Disease Relevance 1.00 Pain Relevance 0.43
S-100B can affect a number of calcium regulated enzymes within astrocytes and it also can be secreted from astrocytes to serve as an intercellular signal between glial cells and neurons [38,40].
Localization (secreted) of S-100B in neurons
2) Confidence 0.11 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.82 Pain Relevance 0.15
S-100B can affect a number of calcium regulated enzymes within astrocytes and it also can be secreted from astrocytes to serve as an intercellular signal between glial cells and neurons [38,40].
Localization (secreted) of S-100B in glial cells
3) Confidence 0.04 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.82 Pain Relevance 0.15

General Comments

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