INT19511

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Context Info
Confidence 0.81
First Reported 1990
Last Reported 2011
Negated 0
Speculated 5
Reported most in Abstract
Documents 212
Total Number 217
Disease Relevance 118.17
Pain Relevance 67.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
macrophages 11
microglia 6
blood 5
astrocytes 4
monocytes 4
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 2086 100.00 Very High Very High Very High
cytokine 1008 100.00 Very High Very High Very High
substance P 281 100.00 Very High Very High Very High
Pain 231 100.00 Very High Very High Very High
Calcitonin gene-related peptide 219 100.00 Very High Very High Very High
Inflammatory mediators 65 100.00 Very High Very High Very High
Enkephalin 19 100.00 Very High Very High Very High
Cholecystokinin 3 100.00 Very High Very High Very High
Dynorphin 2 100.00 Very High Very High Very High
Perioperative pain 7 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2661 100.00 Very High Very High Very High
Cancer 374 100.00 Very High Very High Very High
Pain 244 100.00 Very High Very High Very High
Necrosis 116 100.00 Very High Very High Very High
Obesity 56 100.00 Very High Very High Very High
Pheochromocytoma 38 99.96 Very High Very High Very High
Post Operative Pain 7 99.96 Very High Very High Very High
Injury 435 99.92 Very High Very High Very High
Cv Unclassified Under Development 65 99.92 Very High Very High Very High
Nervous System Injury 143 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible that different individuals release different quantities of IL-6 when presented with the same stimuli.
Localization (release) of IL-6
1) Confidence 0.81 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2702344 Disease Relevance 0.58 Pain Relevance 0.08
We have shown that release of IL-6 was due to fat embolism and secondary lung tissue damage.
Localization (release) of IL-6 in lung associated with cva and fat embolism
2) Confidence 0.81 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2702344 Disease Relevance 0.68 Pain Relevance 0.17
Inflammatory cells are responsible for the release of IL-6.
Localization (release) of IL-6 associated with inflammation
3) Confidence 0.81 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2702344 Disease Relevance 0.70 Pain Relevance 0.15
A direct secretion of IL-6 from brain to blood has been shown to be a major mechanism by which the brain activates peripheral metabolic, endocrine and immune responses.
Localization (secretion) of IL-6 in blood
4) Confidence 0.79 Published 1998 Journal Neuroimmunomodulation Section Abstract Doc Link 9730688 Disease Relevance 0.90 Pain Relevance 0.09
BACKGROUND: We have studied modulation of mucosal interleukin-6 (IL-6) secretion by T-cell activation and by anti-inflammatory agents in inflammatory bowel disease.
Localization (secretion) of IL-6 in bowel associated with inflammation
5) Confidence 0.79 Published 1994 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 7973432 Disease Relevance 0.35 Pain Relevance 0.17
RESULTS: Stimulation of control specimens increased IL-6 secretion (median increase, 147%; p < 0.003), which was prevented by CsA.
Localization (secretion) of IL-6
6) Confidence 0.79 Published 1994 Journal Scand. J. Gastroenterol. Section Body Doc Link 7973432 Disease Relevance 0.16 Pain Relevance 0
To our knowledge, our paper represents the 6th case report of IL-6 secreting pheochromocytoma associated with clinical markers of inflammatory response.
Localization (secreting) of IL-6 associated with inflammatory response and pheochromocytoma
7) Confidence 0.79 Published 2003 Journal J. Endocrinol. Invest. Section Abstract Doc Link 12906374 Disease Relevance 1.09 Pain Relevance 0.38
Mucosal interleukin-6 secretion in ulcerative colitis.
Localization (secretion) of interleukin-6 associated with inflammatory bowel disease
8) Confidence 0.79 Published 1994 Journal Scand. J. Gastroenterol. Section Title Doc Link 7973432 Disease Relevance 0.20 Pain Relevance 0.19
METHODS: In vitro secretion of IL-6 by biopsy specimens from patients with active ulcerative colitis was investigated in the presence of cyclosporin-A (CsA) and drugs that have other anti-inflammatory actions.
Spec (investigated) Localization (secretion) of IL-6
9) Confidence 0.79 Published 1994 Journal Scand. J. Gastroenterol. Section Body Doc Link 7973432 Disease Relevance 0.20 Pain Relevance 0
In quiescent ulcerative colitis there was enhanced spontaneous secretion of IL-6 but a smaller, non-significant increase after T-cell activation (125%).
Localization (secretion) of IL-6 in T-cell
10) Confidence 0.79 Published 1994 Journal Scand. J. Gastroenterol. Section Body Doc Link 7973432 Disease Relevance 0.15 Pain Relevance 0
BACKGROUND: We have studied modulation of mucosal interleukin-6 (IL-6) secretion by T-cell activation and by anti-inflammatory agents in inflammatory bowel disease.
Localization (secretion) of interleukin-6 in bowel associated with inflammation
11) Confidence 0.79 Published 1994 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 7973432 Disease Relevance 0.35 Pain Relevance 0.17
In cell cultures derived from injured nerves, CGRP concentration-dependently increased IL-6 release, an effect also blocked by CGRP antagonists.
Localization (release) of IL-6 in nerves associated with antagonist and calcitonin gene-related peptide
12) Confidence 0.79 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16805807 Disease Relevance 0.77 Pain Relevance 1.29
Both CGRP antagonists significantly reduced IL-6 release from injured nerve explants.
Localization (release) of IL-6 in nerve associated with antagonist and calcitonin gene-related peptide
13) Confidence 0.79 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16805807 Disease Relevance 0.81 Pain Relevance 1.33
Pretreatment with IL-1 receptor antagonist (IL-1ra) attenuated the release of IL-6 and had a marginal effect on the corticosterone response 6 h after turpentine.
Localization (release) of IL-6 associated with antagonist
14) Confidence 0.79 Published 1994 Journal Psychoneuroendocrinology Section Abstract Doc Link 8190836 Disease Relevance 0.14 Pain Relevance 0.17
OBJECTIVES: To determine if there is a release of IL-6 after surgical removal of lower third molars and to compare the amount of IL-6 in patients treated with NSAID and in those treated with glucocorticoids.
Localization (release) of IL-6 in molars associated with cinod
15) Confidence 0.79 Published 2006 Journal Medicina oral, patología oral y cirugía bucal Section Abstract Doc Link 17072258 Disease Relevance 0 Pain Relevance 0.10
LPS stimulated IL-6 release in a concentration-dependent manner from rat cortical type I astrocytes.
Localization (release) of IL-6 in astrocytes
16) Confidence 0.78 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.07 Pain Relevance 0.21
LPS-induced IL-6 release was partially inhibited by BW 4AC, a 5-lipoxygenase inhibitor.
Localization (release) of IL-6
17) Confidence 0.78 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.07 Pain Relevance 0.25
To rule out the possibility that DEX was inhibiting LPS-induced IL-6 release by blocking IL-6 gene expression, we tested the effect of DEX on interleukin 1beta(IL-1)-induced IL-6 release.
Localization (release) of IL-6 associated with dexamethasone
18) Confidence 0.78 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.07 Pain Relevance 0.27
The involvement of nitric oxide (NO) generation on LPS-induced IL-6 release was also studied.
Localization (release) of IL-6
19) Confidence 0.78 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.07 Pain Relevance 0.32
Bacterial lipopolysaccharide increases interleukin-6 and prostaglandin release in rat cortical type I astrocytes by different mechanisms: role of anti-inflammatory agents.
Localization (release) of interleukin-6 in astrocytes associated with inflammation
20) Confidence 0.78 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 9784426 Disease Relevance 0.10 Pain Relevance 0.25

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