INT195110

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 2.88
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc1a3) plasma membrane (Slc1a3)
Anatomy Link Frequency
whisker 4
neuronal 2
brain 2
astrocytes 2
barrel cortex 2
Slc1a3 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 322 100.00 Very High Very High Very High
Somatosensory cortex 15 95.28 Very High Very High Very High
excitatory amino acid 5 94.32 High High
long-term potentiation 5 83.68 Quite High
cerebral cortex 10 82.08 Quite High
Hippocampus 10 82.04 Quite High
Glutamate receptor 15 81.60 Quite High
Nerve growth factor 16 73.04 Quite High
Pyramidal cell 5 56.24 Quite High
anesthesia 14 37.28 Quite Low
Disease Link Frequency Relevance Heat
Injury 225 99.98 Very High Very High Very High
Penetrating Head Injuries 20 99.98 Very High Very High Very High
Stab Wounds 60 99.84 Very High Very High Very High
Epilepsy 10 90.96 High High
Hypoxia 4 85.20 High High
Anxiety Disorder 5 84.68 Quite High
Brain Injury 40 82.20 Quite High
Death 12 78.84 Quite High
Disease 16 78.08 Quite High
Cicatrix 24 30.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we demonstrate that a penetrating brain injury increases the expression of GLT-1 and GLAST.
Positive_regulation (increases) of Gene_expression (expression) of GLAST in brain associated with penetrating head injuries
1) Confidence 0.44 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.56 Pain Relevance 0.27
Similarly, GLT-1 and GLAST mRNA expression are induced after cultured astrocytes are physically traumatized [77,78].
Positive_regulation (induced) of Gene_expression (expression) of GLAST mRNA in astrocytes
2) Confidence 0.44 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.70 Pain Relevance 0.23
Western blot analysis (Figure 1C and 1D) shows that after 24 h of whisker stimulation, GLAST and GLT1 expression increased 2.46-fold and 2.65-fold of the unstimulated value (GLAST: 246 ± 20.9% mean ± standard deviation [SD]; GLT1: 265 ± 38.1%; p < 0.01, Tukey honestly significant difference [HSD]).
Positive_regulation (increased) of Gene_expression (expression) of GLAST in whisker
3) Confidence 0.40 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0 Pain Relevance 0.07
All the evidence supports the idea that regulating the expression of GLT1 and GLAST during a period of increased glutamate release, e.g., during increased sensory stimulation, is necessary for avoiding any effects of glutamate build-up.
Positive_regulation (necessary) of Gene_expression (expression) of GLAST associated with glutamate
4) Confidence 0.38 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0.09 Pain Relevance 0.38
On a longer time scale, however, the expression levels of GLT1 and GLAST have been shown, in vitro, to depend on the level of neuronal activity [14].
Positive_regulation (depend) of Gene_expression (expression) of GLAST in neuronal
5) Confidence 0.38 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0.08 Pain Relevance 0.36
Using mice, we found that 24 h of whisker stimulation elicited a 2-fold increase in the expression of GLT1 and GLAST in the corresponding cortical column of the barrel cortex.
Positive_regulation (increase) of Gene_expression (expression) of GLAST in barrel cortex
6) Confidence 0.38 Published 2006 Journal PLoS Biology Section Abstract Doc Link PMC1609127 Disease Relevance 0 Pain Relevance 0.26
Using Western blot analysis on single barrel columns corresponding to the stimulated whisker, we found that expression levels of GLT1 and GLAST were significantly increased.
Positive_regulation (increased) of Gene_expression (expression) of GLAST in whisker
7) Confidence 0.35 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0.15 Pain Relevance 0.28
Thus, a neocortical stab wound injury induces the expression of GLT-1, GLAST, the GS, and S-100B, but our data indicate that this induction is independent of IL-1R1.
Positive_regulation (induces) of Gene_expression (expression) of GLAST associated with injury and stab wounds
8) Confidence 0.32 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.81 Pain Relevance 0.15
Our results show that in both WT and receptor-null mice, stab wound injury increased GLAST, GLT-1, GS and S-100B protein expression at 3 day post injury by 8, 6, 4 and 12 fold, respectively (Fig. 7).
Positive_regulation (increased) of Gene_expression (expression) of GLAST associated with injury and stab wounds
9) Confidence 0.28 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.49 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox