INT195117

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Context Info
Confidence 0.10
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.26
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ptgs2) enzyme binding (Ptgs2) protein complex (Ptgs2)
cytoplasm (Ptgs2) lipid binding (Ptgs2) extracellular space (Il6)
Ptgs2 (Mus musculus)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 18 100.00 Very High Very High Very High
Inflammation 12 100.00 Very High Very High Very High
Inflammatory mediators 6 100.00 Very High Very High Very High
COX2 2 100.00 Very High Very High Very High
metalloproteinase 2 100.00 Very High Very High Very High
Multiple sclerosis 2 89.84 High High
ischemia 2 71.40 Quite High
antagonist 2 68.40 Quite High
Nerve growth factor 8 63.04 Quite High
Glutamate 46 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 20 100.00 Very High Very High Very High
Cancer 2 99.56 Very High Very High Very High
Necrosis 2 99.32 Very High Very High Very High
Infection 2 93.96 High High
Injury 110 93.52 High High
Demyelinating Disease 2 89.84 High High
Alzheimer's Dementia 2 80.84 Quite High
Down Syndrome 2 77.08 Quite High
Disease 8 76.36 Quite High
Amyloid Plaque 2 74.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-1 subsequently increases the production of inflammatory mediators, such as cyclooxygenase 2, prostanoids, nitric oxide, matrix metalloproteinases, collagenase [17], and pro-inflammatory cytokines, including Interleukin-6 (IL-6) [18,19], tumor necrosis factor alpha (TNF-?)
cyclooxygenase 2 Positive_regulation (mediators) of Gene_expression (production) of IL-6 associated with necrosis, inflammatory mediators, inflammation, cancer, metalloproteinase, cox2 and cytokine
1) Confidence 0.10 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 1.63 Pain Relevance 0.58
IL-1 subsequently increases the production of inflammatory mediators, such as cyclooxygenase 2, prostanoids, nitric oxide, matrix metalloproteinases, collagenase [17], and pro-inflammatory cytokines, including Interleukin-6 (IL-6) [18,19], tumor necrosis factor alpha (TNF-?)
cyclooxygenase 2 Positive_regulation (mediators) of Gene_expression (production) of Interleukin-6 associated with necrosis, inflammatory mediators, inflammation, cancer, metalloproteinase, cox2 and cytokine
2) Confidence 0.10 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 1.63 Pain Relevance 0.58

General Comments

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