INT195122

Context Info Confidence 0.02 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.38 Pain Relevance 0.50

RNA binding (Gtf3a) nucleus (Gtf3a) intracellular (Gtf3a) DNA binding (Gtf3a)

Anatomy Link Frequency fibroblast 2 Il1 (Mus musculus) Gtf3a (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 9 99.98 Inflammation 6 96.00 Nerve growth factor 4 93.60 metalloproteinase 1 85.64 COX2 1 83.48 Inflammatory mediators 3 82.44 Multiple sclerosis 1 70.84 ischemia 1 52.40 antagonist 1 49.40 Glutamate 23 5.00

Disease Link Frequency Relevance Heat Injury 55 99.64 INFLAMMATION 10 96.00 Necrosis 1 89.88 Cancer 1 89.52 Infection 1 74.96 Demyelinating Disease 1 70.84 Disease 4 64.08 Alzheimer's Dementia 1 61.84 Down Syndrome 1 58.08 Amyloid Plaque 1 55.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Contrary to accumulating evidence that portrays IL-1 as a maladaptive injury related cytokine IL-1 increases the expression of multiple growth and trophic factors, including fibroblast growth factor-2 [22], transforming growth factor ?

IL-1 Positive_regulation (increases) of Gene_expression (expression) of factor in fibroblast associated with injury and cytokine

1) Confidence 0.02 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 1.38 Pain Relevance 0.50

General Comments

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