INT195132

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Context Info
Confidence 0.56
First Reported 2006
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 4.12
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gsta2) nucleus (Gsta2)
Anatomy Link Frequency
glial cells 1
neurons 1
plaque 1
lung 1
Gsta2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 54 99.60 Very High Very High Very High
qutenza 58 83.28 Quite High
Potency 2 46.40 Quite Low
nociceptor 45 46.20 Quite Low
imagery 33 38.64 Quite Low
antagonist 2 5.16 Low Low
Pain 33 5.00 Very Low Very Low Very Low
tetrodotoxin 30 5.00 Very Low Very Low Very Low
TRP channel 15 5.00 Very Low Very Low Very Low
fifth nerve 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 204 98.58 Very High Very High Very High
Toxicity 6 94.84 High High
Cancer 89 89.68 High High
Sprains And Strains 42 85.28 High High
Cytomegalovirus Infection 12 79.92 Quite High
Viral Infection 12 79.48 Quite High
Colon Cancer 18 78.92 Quite High
Reprotox - General 1 10 75.60 Quite High
Skin Cancer 2 74.12 Quite High
Bronchogenic Carcinoma 6 73.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, in BBs taken from smokers, expression of EPHX1 was significantly lower (p < 0.001), whereas the expression of GSTA2 and GSTP1 were up to triple that in non-smokers.
Gene_expression (expression) of GSTA2 associated with nicotine addiction
1) Confidence 0.56 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.74 Pain Relevance 0
Expression of GSTA2 and GSTM1 was not different between the study groups (Figure 2).
Gene_expression (Expression) of GSTA2
2) Confidence 0.56 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.75 Pain Relevance 0
We investigated the gene expression of 19 cytochrome P450 monooxygenases (CYPs) and 3 flavin-containing monooxygenases (FMOs), as well as uridine diphosphate glucuronosyltransferase (UGT) 2A1 (UGT2A1), epoxide hydrolase (EPHX1), glutathione-S-transferase (GST) A2 (GSTA2), GSTP1, and GSTM1 in lung cells obtained from bronchoalveolar lavage (BAL) fluid and in bronchial biopsies (BBs) of smokers (n = 8) and nonsmokers (n = 10).
Spec (investigated) Gene_expression (expression) of GSTA2 in lung associated with nicotine addiction
3) Confidence 0.43 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.68 Pain Relevance 0
/RXR-mediated GSTA2 induction in the
Gene_expression (induction) of GSTA2
4) Confidence 0.26 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528242 Disease Relevance 0.66 Pain Relevance 0.25
and RXR agonists could increase the expression of GSTA2 but treatment of cells
Gene_expression (expression) of GSTA2 associated with agonist
5) Confidence 0.23 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528242 Disease Relevance 0.70 Pain Relevance 0.24
DNA of single plaque isolates was tested by Southern blot analysis for correct recombination (data not shown) and absence of gG but presence of YC2.1 expression was tested in western blot analysis of infected cell lysates (data not shown).
Gene_expression (expression) of YC2 in plaque
6) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1533842 Disease Relevance 0.25 Pain Relevance 0
Keeping cells two days in vitro resulted in pronounced viral spread in the culture dish due to ongoing viral replication and YC2.1-fluorescence could be detected in nearly all cell types including neurons and glial cells.
Gene_expression (detected) of YC2 in glial cells
7) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1533842 Disease Relevance 0.16 Pain Relevance 0
Keeping cells two days in vitro resulted in pronounced viral spread in the culture dish due to ongoing viral replication and YC2.1-fluorescence could be detected in nearly all cell types including neurons and glial cells.
Gene_expression (detected) of YC2 in neurons
8) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1533842 Disease Relevance 0.16 Pain Relevance 0

General Comments

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