INT195134

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.82
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm8) transmembrane transport (Trpm8)
Anatomy Link Frequency
ganglia 1
Trpm8 (Mus musculus)
Pain Link Frequency Relevance Heat
chronic construction injury 29 99.54 Very High Very High Very High
Potency 4 95.76 Very High Very High Very High
qutenza 44 91.60 High High
Pain 41 86.16 High High
primary afferent fibers 2 85.24 High High
agonist 43 85.20 High High
TRP channel 19 83.92 Quite High
Peripheral nervous system 4 81.68 Quite High
antagonist 27 81.44 Quite High
fifth nerve 8 70.64 Quite High
Disease Link Frequency Relevance Heat
Injury 68 99.54 Very High Very High Very High
Hypersensitivity 67 98.46 Very High Very High Very High
Pain 42 86.16 High High
Nociception 24 72.76 Quite High
Sprains And Strains 29 53.68 Quite High
Neuropathic Pain 55 50.00 Quite Low
Pseudorabies 6 15.36 Low Low
Infection 42 5.00 Very Low Very Low Very Low
Ganglion Cysts 24 5.00 Very Low Very Low Very Low
Nervous System Injury 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, our data suggest a sequential model of TRPM8 gating where chemical modulators can favour (e.g. menthol) or hinder (e.g.
TRPM8 Binding (hinder) of
1) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2778643 Disease Relevance 0 Pain Relevance 0.18
The results of the in vivo studies with icilin and LPC agree well with our earlier in vitro studies [6] demonstrating that LPLs produced by iPLA2 play an important role in regulating the cold sensitivity of TRPM8. iPLA2 inhibition with BEL reduced the cold hypersensitivity induced by icilin, consistent with our in vitro findings that BEL inhibited TRPM8 responses to icilin.
TRPM8 Binding (responses) of associated with hypersensitivity
2) Confidence 0.37 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.23 Pain Relevance 0.04
A chemosensitive function can also be attributed to the TRPM8 (CMR1) receptor channel, which can be activated by cooling compounds such as menthol, menthone, eucalyptol and icilin [8,9].
CMR1 Binding (attributed) of
3) Confidence 0.36 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1533842 Disease Relevance 0.22 Pain Relevance 0.48
In further experiments, individual L4 and L5 ganglia were dissected from control and CCI rats and processed as above for qRT-PCR of TRPM8, TRPA1 and GAPDH mRNA.


TRPM8 Binding (above) of in ganglia associated with chronic construction injury
4) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.16 Pain Relevance 0.08
A chemosensitive function can also be attributed to the TRPM8 (CMR1) receptor channel, which can be activated by cooling compounds such as menthol, menthone, eucalyptol and icilin [8,9].
TRPM8 Binding (attributed) of
5) Confidence 0.31 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1533842 Disease Relevance 0.22 Pain Relevance 0.48

General Comments

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