INT195185

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.29
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Msn) nucleolus (Msn) plasma membrane (Msn)
cytoskeleton (Msn) nucleus (Msn) protein binding, bridging (Msn)
Anatomy Link Frequency
DA neuron 2
dendritic tree 2
Msn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pyramidal cell 168 100.00 Very High Very High Very High
GABAergic 15 99.96 Very High Very High Very High
Nucleus accumbens 155 99.88 Very High Very High Very High
Dopamine 202 98.72 Very High Very High Very High
Action potential 14 95.28 Very High Very High Very High
antagonist 9 91.76 High High
repetitive firing 2 72.96 Quite High
Neuronal excitability 2 72.08 Quite High
potassium channel 3 70.60 Quite High
agonist 21 68.80 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 31 88.40 High High
Parkinson's Disease 5 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low
Hypersensitivity 3 5.00 Very Low Very Low Very Low
Anaerobic Bacterial Infections 2 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 2 5.00 Very Low Very Low Very Low
Aids-related Complex 1 5.00 Very Low Very Low Very Low
Respiratory Tract Infection 1 5.00 Very Low Very Low Very Low
Arrhythmias 2 Under Development 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the shell of the Acb, the dimensions of the dendritic tree of MSN ranged from 62 up to 375 ?
Regulation (ranged) of Regulation (dimensions) of MSN in dendritic tree associated with nucleus accumbens and pyramidal cell
1) Confidence 0.38 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0.07 Pain Relevance 0.56
As same changes were detected in dopamine depletion, this strongly suggests a pivotal, if not exclusive, role of this current in the alterations in MSN intrinsic excitability observed in this condition.
Regulation (role) of Regulation (alterations) of MSN associated with dopamine
2) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.32
Presynaptic D2 autoreceptors on DA neuron terminals inhibit DA release [71], D2 heteroreceptors on corticostriatal terminals inhibit glutamatergic inputs [72], and presynaptic D1 and D2 heteroreceptors on MSN terminals modulate GABAergic IPSCs [present results, and Refs. [9,73]].
Regulation (modulate) of Regulation (heteroreceptors) of MSN in DA neuron associated with dopamine and gabaergic
3) Confidence 0.30 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0.22 Pain Relevance 0.58

General Comments

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