INT195187

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 15
Disease Relevance 0.38
Pain Relevance 3.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Msn) nucleolus (Msn) plasma membrane (Msn)
cytoskeleton (Msn) nucleus (Msn) protein binding, bridging (Msn)
Anatomy Link Frequency
neuronal 1
shell 1
MSN 1
anatomy 1
synapses 1
Msn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pyramidal cell 168 100.00 Very High Very High Very High
Dopamine 1132 99.84 Very High Very High Very High
Nucleus accumbens 195 99.68 Very High Very High Very High
potassium channel 33 98.20 Very High Very High Very High
Neuronal excitability 22 96.84 Very High Very High Very High
midbrain 37 96.76 Very High Very High Very High
Action potential 144 96.24 Very High Very High Very High
repetitive firing 12 95.80 Very High Very High Very High
substance P 1 94.40 High High
Enkephalin 46 81.92 Quite High
Disease Link Frequency Relevance Heat
Pulmonary Fibrosis 6 58.48 Quite High
Asthma 10 58.00 Quite High
Cancer 26 56.24 Quite High
Drug Dependence 11 51.44 Quite High
Wound Healing 2 50.72 Quite High
Disease 13 49.08 Quite Low
Pulmonary Disease 2 35.04 Quite Low
Cystic Fibrosis 2 32.00 Quite Low
Cognitive Disorder 11 24.84 Low Low
INFLAMMATION 6 13.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under these conditions, despite that the stimulation threshold current to evoke an EPSP is increased in dopamine-depleted animals, the initial linear slope factor of the stimulation-EPSP slope plots is significantly and dramatically increased in MSN from dopamine-depleted animals (0.66±0.26 mV.ms?
Positive_regulation (increased) of MSN associated with dopamine
1) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.23
The facilitation in cell depolarization in response to a subthreshold current pulse, which is strongly dependent on IA [17], [18], is an additional argument involving this current in the increase in MSN excitability.
Positive_regulation (increase) of MSN
2) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.28
The minimal stimulation threshold current to evoke an EPSP is significantly increased in MSN from dopamine-depleted animals as compared to controls (0.5±0.1 mA for untreated control animals, n?
Positive_regulation (increased) of MSN associated with dopamine
3) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.26
The majority of proteins that were up-regulated were related to calcium signaling and cytoskeletal organization, as evidenced by the strong increases in ANXV and ANXVI, Msn, RhoGDI, PIPTN, calcyclin, and Arp3.
Positive_regulation (increases) of Msn
4) Confidence 0.44 Published 2007 Journal Respir Res Section Body Doc Link PMC1876226 Disease Relevance 0.22 Pain Relevance 0.06
Fig. 5Three-dimensional (3D) reconstruction of a single MSN in the Acb core subregion in close vicinity to the shell-core boundary. a The neuron (neuron 5-IV) is located in the rostromedial part of the core subregion of the Acb, along the shell-core boundary at a range of approximately 60 ?
Positive_regulation (reconstruction) of MSN in shell associated with nucleus accumbens and pyramidal cell
5) Confidence 0.43 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.22
Therefore, the increase in excitability may result from a homeostatic response of MSN to the loss of excitatory synaptic inputs in case of dopamine depletion.
Positive_regulation (response) of MSN associated with dopamine
6) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.14
This anatomy is consistent with physiological studies, in which MSN-to-MSN connections were activated by antidromic activation from the ventral pallidum.
Positive_regulation (activated) of MSN in anatomy
7) Confidence 0.34 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0 Pain Relevance 0.32
In the present study, we showed that dopamine depletion leads to an increase in MSN intrinsic excitability both in a reserpine-treatment induced dopamine depletion and in a 6-OHDA induced degeneration of dopaminergic neurons.
Positive_regulation (increase) of MSN in dopaminergic neurons associated with dopamine
8) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.32
We also showed that this increase in MSN intrinsic excitability takes place through the decrease in IA.
Positive_regulation (increase) of MSN
9) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.33
Here, using perforated patch-clamp recordings, we investigated the alterations in MSN intrinsic excitability induced by dopamine depletion.
Positive_regulation (induced) of MSN in MSN associated with dopamine
10) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0.05 Pain Relevance 0.17
In both models of dopamine depletion used in the present study, the MSN intrinsic excitability was dramatically increased.
Positive_regulation (increased) of MSN associated with dopamine
11) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.28
We hypothesized that this increase in MSN intrinsic excitability could involve A-type potassium channels, which control neuronal excitability and repetitive firing [25].
Positive_regulation (increase) of MSN in neuronal associated with neuronal excitability, repetitive firing and potassium channel
12) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.30
We demonstrated that, despite the large decrease in their excitatory synaptic inputs, this increase in MSN intrinsic excitability resulted in an enhanced responsiveness to their remaining synapses, allowing them to fire similarly or even more efficiently following input stimulation than in control condition.
Positive_regulation (increase) of MSN in synapses
13) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.38
We therefore asked whether the increase in MSN excitability in dopamine-depleted rats could also be sustained by a modification of the A-type K+ current.
Spec (whether) Positive_regulation (increase) of MSN associated with dopamine
14) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.36
Actin polymerization could subsequently enhance the dynamic relocation of cytoskeleton-linking attachment proteins [19] such as moesin, also observed to be increased in this study.
Positive_regulation (increased) of moesin
15) Confidence 0.29 Published 2007 Journal Respir Res Section Body Doc Link PMC1876226 Disease Relevance 0.11 Pain Relevance 0

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