INT1952

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Context Info
Confidence 0.51
First Reported 1978
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 33
Total Number 33
Disease Relevance 15.80
Pain Relevance 7.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
microglia 10
macrophages 4
embryo 2
cardiac myocyte 2
Kupffer cells 2
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 33 100.00 Very High Very High Very High
local anesthetic 12 99.96 Very High Very High Very High
fibrosis 11 99.90 Very High Very High Very High
adenocard 76 99.84 Very High Very High Very High
cva 17 99.68 Very High Very High Very High
Inflammatory response 72 99.64 Very High Very High Very High
antagonist 45 98.88 Very High Very High Very High
Arthritis 5 98.56 Very High Very High Very High
cytokine 364 97.40 Very High Very High Very High
cINOD 58 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cardiovascular Disorder Under Development 2 99.90 Very High Very High Very High
Infection 160 99.84 Very High Very High Very High
Hemorrhage 16 99.68 Very High Very High Very High
INFLAMMATION 582 99.64 Very High Very High Very High
Death 66 99.60 Very High Very High Very High
Disease 225 99.32 Very High Very High Very High
Injury 145 99.32 Very High Very High Very High
Embryo Loss 9 99.24 Very High Very High Very High
Toxicity 5 99.08 Very High Very High Very High
Spontaneous Abortion 34 98.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that the drug induced inhibition of LPS activation was due solely to the toxicity of the compounds.
Negative_regulation (inhibition) of Positive_regulation (activation) of LPS associated with toxicity
1) Confidence 0.51 Published 1978 Journal Scand. J. Immunol. Section Abstract Doc Link 306664 Disease Relevance 0.17 Pain Relevance 0.08
Activation of cultured microglia with toll-like receptor 2 (TLR2), TLR4, or TLR9 ligand markedly boosted ingestion of A?
Negative_regulation (boosted) of Positive_regulation (Activation) of TLR4 in microglia
2) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.34 Pain Relevance 0.15
In contrast, previous studies from our laboratory have identified TLR4 as mediating LPS-induced impairment of LV function, cardiac myocyte contractility, intramyocardial cytokine expression and NO production, as well as significant activation of myocardial NF?
Negative_regulation (identified) of Positive_regulation (mediating) of LPS in cardiac myocyte associated with cytokine
3) Confidence 0.36 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1933437 Disease Relevance 0.16 Pain Relevance 0.13
The decrease in gastric emptying in response to LPS administration was unlikely to be a non-specific hemodynamic effect as mean arterial blood pressure remained unchanged relative to controls for 60 minutes after administration of 0.1 mg/kg LPS (Figure 10) yet a significant reduction in gastric emptying was evident within 1 hour after insult (Figure 9A).
Negative_regulation (decrease) of Positive_regulation (response) of LPS in blood
4) Confidence 0.36 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1177942 Disease Relevance 0 Pain Relevance 0
Cardiac fibrosis was reduced through inducing TLR4 signalling [73].
Negative_regulation (reduced) of Positive_regulation (inducing) of TLR4 associated with fibrosis and cardiovascular disorder under development
5) Confidence 0.31 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 1.06 Pain Relevance 0.23
As depicted by the figure 1D (ipsilateral side), most genes differently expressed when evaluating the effect of RU486 on LPS-treatment (LPS/RU486–LPS contrast) were those wherein LPS upregulation was prevented (or partially prevented in at least 50%) by GR blockage.
Negative_regulation (prevented) of Positive_regulation (upregulation) of LPS
6) Confidence 0.30 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.12 Pain Relevance 0.06
For ibuprofen, the EC50 for suppressing ICV LPS-induced F4-NeuroPs is between 0.1 and 0.5 ?
Negative_regulation (suppressing) of Positive_regulation (induced) of ICV LPS associated with intracerebroventricular
7) Confidence 0.30 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC527876 Disease Relevance 0.74 Pain Relevance 0.83
In support of the idea that the expression of TLR4 on Kupffer cells is essential for injury, destruction of these cells also prevented increases in TLR-4 expression [9].
Negative_regulation (prevented) of Positive_regulation (increases) of TLR-4 in Kupffer cells associated with injury
8) Confidence 0.30 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 1.35 Pain Relevance 0.19
The innate immunity is rapidly triggered after LPS, primarily via activation of toll-like receptor 4 (TLR-4) [17].
Negative_regulation (triggered) of Positive_regulation (activation) of TLR-4
9) Confidence 0.26 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 1.07 Pain Relevance 0.49
The innate immunity is rapidly triggered after LPS, primarily via activation of toll-like receptor 4 (TLR-4) [17].
Negative_regulation (triggered) of Positive_regulation (activation) of toll-like receptor 4
10) Confidence 0.26 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 1.07 Pain Relevance 0.49
Previous studies have demonstrated that LPS treatment of macrophages can induce a concomitant increase in TNF synthesis and PGE2 production, and that LPS-induced TNF production by macrophages is suppressed by submicromolar concentrations of exogenous PGE2 [14, 15].
Negative_regulation (suppressed) of Positive_regulation (induced) of LPS in macrophages
11) Confidence 0.26 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0 Pain Relevance 0
As shown in Figure 2A, Bay117082 markedly inhibited LPS-induced COX-2 expression, suggesting that NF-?
Negative_regulation (inhibited) of Positive_regulation (induced) of LPS
12) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0 Pain Relevance 0
In the present study, we found that LPS-induced COX-2 expression and p65 activation was inhibited by pretreatment with CoPP and CO-RM2, suggesting that induction of HO-1/CO inhibits LPS-induced COX-2 by inhibition of NF-?
Negative_regulation (inhibits) of Positive_regulation (induced) of LPS
13) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.28 Pain Relevance 0.12
Recently, CO has also been shown to block LPS-induced initial inflammatory response through inhibition of NF-?
Negative_regulation (block) of Positive_regulation (induced) of LPS associated with inflammatory response
14) Confidence 0.22 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.33 Pain Relevance 0.13
In the blood/vascular system, pretreatment of human umbilical vein endothelial cells (HUVEC) with CO-RM2 attenuates the LPS-induced activation of NF-?
Negative_regulation (attenuates) of Positive_regulation (activation) of LPS in endothelial cells
15) Confidence 0.22 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.33 Pain Relevance 0.13
CD86 RNA expression after 24 hrs of LPS stimulation with 0, 1, 5, or 10 ?
Negative_regulation (hrs) of Positive_regulation (stimulation) of LPS in CD86
16) Confidence 0.22 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0 Pain Relevance 0.07
Treatment of microglial cells with activin A (n = 3 experiments, dark gray bars) reversed the effects of LPS as groups treated with LPS and activin A showed similar levels of ramified (resting) microglial cells and amoeboid (activated) microglial cells as seen in microglia that were not stimulated with LPS.
Negative_regulation (reversed) of Positive_regulation (effects) of LPS in microglial cells
17) Confidence 0.20 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0 Pain Relevance 0
Previous studies have reported on impaired induction of G-CSF in LPS-stimulated macrophages derived from mice expressing only the dominant-negative LIP form of c/ebp Beta (33).
Negative_regulation (impaired) of Positive_regulation (induction) of LPS in macrophages
18) Confidence 0.17 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 1.43 Pain Relevance 0.45
in response to LPS is efficiently reduced by ?
Negative_regulation (reduced) of Positive_regulation (response) of LPS
19) Confidence 0.16 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3017519 Disease Relevance 0.42 Pain Relevance 0.47
Moreover, NO secretion was completely blocked in LPS-activated microglia upon co-incubation with luteolin.
Negative_regulation (blocked) of Positive_regulation (incubation) of LPS in microglia
20) Confidence 0.15 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0.19 Pain Relevance 0

General Comments

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