INT195203

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Context Info
Confidence 0.32
First Reported 2006
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 13.97
Pain Relevance 8.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tenc1)
Anatomy Link Frequency
ventricles 1
liver 1
brain 1
upper 1
Tenc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 328 100.00 Very High Very High Very High
Lasting pain 44 100.00 Very High Very High Very High
Hyperalgesia 40 99.72 Very High Very High Very High
Pain 436 98.80 Very High Very High Very High
depression 12 98.16 Very High Very High Very High
syringomyelia 8 97.84 Very High Very High Very High
Pain score 36 97.08 Very High Very High Very High
allodynia 52 96.64 Very High Very High Very High
Post herpetic neuralgia 28 95.92 Very High Very High Very High
reflex sympathetic dystrophy 28 94.48 High High
Disease Link Frequency Relevance Heat
Pain 544 100.00 Very High Very High Very High
Neuropathic Pain 456 100.00 Very High Very High Very High
Normal Pressure Hydrocephalus 96 100.00 Very High Very High Very High
Hyperalgesia 60 99.72 Very High Very High Very High
Disease 309 99.70 Very High Very High Very High
Diabetes Mellitus 28 99.64 Very High Very High Very High
Urological Neuroanatomy 15 99.60 Very High Very High Very High
Syndrome 55 99.42 Very High Very High Very High
Depression 12 98.16 Very High Very High Very High
Syringomyelia 8 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NeP is often associated with comorbid conditions such as poor sleep, depression, mood disturbances, and a lowered quality of life (QoL) [6].
NeP Binding (associated) of associated with depression and neuropathic pain
1) Confidence 0.32 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1947963 Disease Relevance 2.40 Pain Relevance 2.37
Previous studies have indicated increased MPO activity following NEP inhibition (Umeno et al. 1989; Barbara et al. 2003).
NEP Neg (inhibition) Binding (inhibition) of associated with urological neuroanatomy
2) Confidence 0.32 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 1.73 Pain Relevance 0.24
NeP is thought to be present in ~25% of chronic pain patients [3], but remains frequently undiagnosed.
NeP Binding (undiagnosed) of associated with lasting pain and neuropathic pain
3) Confidence 0.25 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1947963 Disease Relevance 2.38 Pain Relevance 2.29
The AD subjects with increased CSFP in this report cannot, strictly speaking, be called NPH, since they had neither the clinical syndrome nor the enlarged ventricles associated with NPH, otherwise they would have been excluded from enrollment.
NPH Binding (associated) of in ventricles associated with normal pressure hydrocephalus, syndrome and disease
4) Confidence 0.24 Published 2006 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1538629 Disease Relevance 1.84 Pain Relevance 0.15
Pathologies typically associated with NeP scored above 12 on the LANSS scale, contrary to pathologies generally considered as being of non-neuropathic origin.


NeP Binding (associated) of associated with neuropathic pain
5) Confidence 0.24 Published 2007 Journal BMC Public Health Section Abstract Doc Link PMC1947963 Disease Relevance 1.44 Pain Relevance 1.20
Diseases that are known to be associated with NeP such as diabetes mellitus (mean LANSS score = 14.4), syringomyelia (17.5), thalamic syndrome (18.1), post-herpetic neuralgia (17.2), and CRPS type 2 (16.6) yielded higher mean LANSS scores than pathologies that are generally considered to be associated with NocP, e.g.
NeP Binding (associated) of associated with syringomyelia, neuralgia, syndrome, diabetes mellitus, neuropathic pain, herpes simplex virus infection, disease, reflex sympathetic dystrophy, painful pain and post herpetic neuralgia
6) Confidence 0.24 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1947963 Disease Relevance 2.22 Pain Relevance 1.54
If the opening CSFP was >200 mmH2O, generally accepted as the upper limit of normal CSFP in adults, the subject was excluded from the trial by protocol, because of probable associated early NPH.
NPH Binding (associated) of in upper associated with normal pressure hydrocephalus
7) Confidence 0.21 Published 2006 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1538629 Disease Relevance 0.69 Pain Relevance 0.18
Both wild-type NEP and sNEP were capable of promoting A?
wild-type NEP Binding (Both) of
8) Confidence 0.21 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0 Pain Relevance 0
Several studies point to NEP as one of the prominent A?
NEP Binding (point) of
9) Confidence 0.21 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0 Pain Relevance 0.08
Mouse lung and kidney express high levels of NEP that comigrates with transfected human NEP, whereas the liver lacks NEP expression (Figure 1A).
NEP Binding (comigrates) of in liver
10) Confidence 0.21 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0.06 Pain Relevance 0.07
While the CSR peptides themselves may offer a potential target in the struggle to prevent abnormal protein aggregation in the brain, our results suggest that simply increasing IDE and NEP activity may not be as beneficial as anticipated.
NEP Binding (activity) of in brain
11) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.35 Pain Relevance 0
Some peptides were generated by both NEP and IDE (e.g.
NEP Binding (generated) of
12) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0 Pain Relevance 0.04
NEP digests preferentially monomeric and oligomeric AChE586-599
NEP Binding (oligomeric) of
13) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0 Pain Relevance 0.04
At the genetic level, at least two single nucleotide polymorphisms (SNPs) located within introns of the NEP gene have been positively associated with AD [112], and an NEP GT-repeat polymorphism is also associated with the late-onset form of the disease [113].
NEP Binding (associated) of associated with disease
14) Confidence 0.05 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.84 Pain Relevance 0.08

General Comments

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