INT195213

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.50
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (HBS1L) translation (HBS1L) GTPase activity (HBS1L)
Anatomy Link Frequency
B lymphocyte 2
HBS1L (Homo sapiens)
Pain Link Frequency Relevance Heat
Perioperative pain 2 80.44 Quite High
ischemia 4 76.84 Quite High
cytokine 20 72.72 Quite High
Pain 6 5.00 Very Low Very Low Very Low
pruritus 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thalassemia 60 99.76 Very High Very High Very High
Hemoglobinopathy 2 99.00 Very High Very High Very High
Sickle Cell Anemia 45 98.54 Very High Very High Very High
Immunization 17 94.12 High High
Chronic Renal Failure 6 92.16 High High
Anaemia 9 80.64 Quite High
Post Operative Pain 2 80.44 Quite High
Acidosis 3 77.36 Quite High
Cv Unclassified Under Development 4 76.84 Quite High
Disease 13 74.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
thalassemia mutations on the clinical severity of HbS-?
Positive_regulation (severity) of Gene_expression (severity) of HbS associated with thalassemia
1) Confidence 0.15 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009427 Disease Relevance 1.41 Pain Relevance 0
It is effective in inducing HBs antibody production by increasing T and B lymphocyte responsiveness, probably through facilitating a greater contact with the antigen overtime [20-22].
Positive_regulation (inducing) of Gene_expression (production) of HBs in B lymphocyte
2) Confidence 0.13 Published 2006 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1540413 Disease Relevance 0.79 Pain Relevance 0
SCD is a haemoglobinopathy characterized by an abnormal haemoglobin variant termed haemoglobin S (HbS).
Positive_regulation (termed) of Gene_expression (termed) of HbS associated with sickle cell anemia and hemoglobinopathy
3) Confidence 0.04 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2838918 Disease Relevance 1.07 Pain Relevance 0.12
Overall, these data show that IMP321 as an adjuvant to non-absorbed HBsAg, is able to induce HBsAg antibodies in 43 % of naïve individuals (i.e. 13 out of 30), with seroprotection being obtained in 2 and 5 naïve subjects following the second and the third immunization, respectively.


Positive_regulation (induce) of Gene_expression (antibodies) of HBsAg associated with immunization
4) Confidence 0.03 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0.24 Pain Relevance 0.04

General Comments

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