INT19527

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Context Info
Confidence 0.51
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 26
Total Number 27
Disease Relevance 15.40
Pain Relevance 11.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Il1a) extracellular space (Il1a) extracellular region (Il1a)
Anatomy Link Frequency
paw 6
hippocampal formation 2
chondrocytes 2
cartilage 2
fibroblasts 2
Il1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 335 100.00 Very High Very High Very High
cytokine 207 100.00 Very High Very High Very High
agonist 192 100.00 Very High Very High Very High
Hyperalgesia 99 100.00 Very High Very High Very High
antagonist 50 100.00 Very High Very High Very High
diclofenac 5 100.00 Very High Very High Very High
dexamethasone 38 99.88 Very High Very High Very High
electroacupuncture 24 99.84 Very High Very High Very High
withdrawal 13 99.74 Very High Very High Very High
intrathecal 8 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 368 100.00 Very High Very High Very High
Hyperalgesia 115 100.00 Very High Very High Very High
Rheumatoid Arthritis 72 99.96 Very High Very High Very High
Hypersensitivity Vasculitis 4 98.96 Very High Very High Very High
Arthritis 302 98.80 Very High Very High Very High
Neuropathic Pain 86 98.42 Very High Very High Very High
Stress 60 98.40 Very High Very High Very High
Diabetes Mellitus 16 98.08 Very High Very High Very High
Inflammatory Pain 13 97.20 Very High Very High Very High
Heat Stroke 114 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The above results suggested that intrahippocampal enkephalin might play an important role in neuro-immunomodulation by enhancing the inhibition of IL-1 alpha gene expression in hippocampal formation.
Negative_regulation (inhibition) of Gene_expression (expression) of IL-1 alpha gene in hippocampal formation associated with enkephalin
1) Confidence 0.51 Published 1996 Journal Sheng Li Xue Bao Section Abstract Doc Link 9389197 Disease Relevance 0 Pain Relevance 0.77
These results indicate that etodolac is an anti-inflammatory drug which suppress IL-1 beta-stimulated PGE2 biosynthesis in rabbit articular chondrocytes, active oxygen generation and bradykinin formation.
Negative_regulation (suppress) of Gene_expression (biosynthesis) of IL-1 in chondrocytes associated with inflammation and bradykinin
2) Confidence 0.41 Published 1994 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 7708812 Disease Relevance 0.28 Pain Relevance 0.50
The results suggest that this orally active inhibitor of IL-1 generation, E5090, may be a therapeutically useful antiinflammatory drug with a novel mechanism of action.
Negative_regulation (inhibitor) of Gene_expression (generation) of IL-1 associated with inflammation
3) Confidence 0.41 Published 1991 Journal Agents Actions Suppl. Section Abstract Doc Link 2069090 Disease Relevance 1.04 Pain Relevance 0.36
E5090 is a novel orally active inhibitor of IL-1 generation without cyclooxygenase-inhibiting activity.
Negative_regulation (inhibitor) of Gene_expression (generation) of IL-1
4) Confidence 0.41 Published 1991 Journal Agents Actions Suppl. Section Abstract Doc Link 2069090 Disease Relevance 0.72 Pain Relevance 0.15
Antiinflammatory properties of E5090, a novel orally active inhibitor of IL-1 generation.
Negative_regulation (inhibitor) of Gene_expression (generation) of IL-1 associated with inflammation
5) Confidence 0.40 Published 1991 Journal Agents Actions Suppl. Section Title Doc Link 2069090 Disease Relevance 0.92 Pain Relevance 0.32
APZ was shown to be a potent inhibitor of the production of leucocyte superoxide and synovial interleukin-1 (IL-1)-like activity and stimulated articular cartilage proteoglycan synthesis, but was ineffective as an inhibitor of platelet aggregation or IL-1 induced cartilage degradation in-vitro.
Spec (like) Negative_regulation (inhibitor) of Gene_expression (production) of IL-1 in cartilage
6) Confidence 0.39 Published 1989 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2569519 Disease Relevance 0.17 Pain Relevance 0.13
Down-regulation of IL-1RI expression by repeated intrathecal antisense ODN (50 microg/10 microl) significantly increased the mean PWL up to 5.75+/-0.15 s in 180-300 min post-carrageenan injection.
Negative_regulation (Down-regulation) of Gene_expression (expression) of IL-1RI associated with intrathecal
7) Confidence 0.26 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19022353 Disease Relevance 0.58 Pain Relevance 1.37
And also EA partly reversed the elevation of IL-1beta and IL-1RI expression induced by carrageenan.
Negative_regulation (reversed) of Gene_expression (expression) of IL-1RI associated with electroacupuncture
8) Confidence 0.26 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19022353 Disease Relevance 0.59 Pain Relevance 1.37
RESULTS: FR133605 inhibited IL-1 and TNF-alpha production stimulated with lipopolysaccharide (LPS) in human monocytes.
Negative_regulation (inhibited) of Gene_expression (production) of IL-1 in monocytes
9) Confidence 0.22 Published 1996 Journal J. Rheumatol. Section Body Doc Link 8895158 Disease Relevance 0.18 Pain Relevance 0
CTX also reduced the production of TNF-alpha, IL-1, and IL-2 but increased the production of IL-10 and altered pathohistological changes.
Negative_regulation (reduced) of Gene_expression (production) of IL-1
10) Confidence 0.13 Published 2009 Journal Acta Pharmacol. Sin. Section Body Doc Link 19169271 Disease Relevance 0.16 Pain Relevance 0
We found that addition of glucosamine to the culture medium had no apparent stimulatory effect on the expression of biosynthetic genes but was a surprisingly effective inhibitor of IL-1?
Negative_regulation (inhibitor) of Gene_expression (effective) of IL-1
11) Confidence 0.13 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.24 Pain Relevance 0.08
Purified human interleukin-1 (IL-1) given locally or systemically also produced bilateral hind paw hyperalgesia which was abolished by local administration of indomethacin.
Negative_regulation (abolished) of Gene_expression (produced) of IL-1 in paw associated with hyperalgesia
12) Confidence 0.11 Published 1988 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 3264514 Disease Relevance 0.57 Pain Relevance 0.41
RhIL-1 beta (20 pg/kg)-induced hyperalgesia was completely blocked by the simultaneous injection of IL-1 receptor antagonist (IL-1ra, 20 ng/kg), Na salicylate (200 ng/kg) or alpha-melanocyte-stimulating hormone alpha-MSH, 20 ng/kg).
Negative_regulation (blocked) of Gene_expression (injection) of IL-1 in melanocyte associated with hyperalgesia and antagonist
13) Confidence 0.10 Published 1995 Journal Brain Res. Section Abstract Doc Link 8624721 Disease Relevance 0.51 Pain Relevance 0.23
The TNF-alpha (10 pg)-induced reduction in paw withdrawal latency was blocked by simultaneous injection of diclofenac (1 ng), a cyclooxygenase inhibitor, or interleukin-1 receptor antagonist (IL-1 ra, 10 ng).
Negative_regulation (inhibitor) of Gene_expression (injection) of IL-1 in paw associated with antagonist, rheumatoid arthritis, diclofenac and withdrawal
14) Confidence 0.09 Published 1996 Journal Neuroimmunomodulation Section Abstract Doc Link 8945729 Disease Relevance 1.18 Pain Relevance 0.56
The TNF-alpha (10 pg)-induced reduction in paw withdrawal latency was blocked by simultaneous injection of diclofenac (1 ng), a cyclooxygenase inhibitor, or interleukin-1 receptor antagonist (IL-1 ra, 10 ng).
Negative_regulation (blocked) of Gene_expression (injection) of IL-1 in paw associated with antagonist, rheumatoid arthritis, diclofenac and withdrawal
15) Confidence 0.09 Published 1996 Journal Neuroimmunomodulation Section Abstract Doc Link 8945729 Disease Relevance 1.19 Pain Relevance 0.57
As mentioned previously, we demonstrated that both TZDs reduced the expression of IL-1?
Negative_regulation (reduced) of Gene_expression (expression) of IL-1
16) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374462 Disease Relevance 1.23 Pain Relevance 0.28
(0.01 ng/ml) and FGF8 (100 ng/ml) for 48 hours, there was a significant decrease in residual S-GAG compared with levels after FGF8 stimulation or IL-1?
Negative_regulation (compared) of Gene_expression (levels) of IL-1
17) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0 Pain Relevance 0
However, whatever the RAR siRNA used, ATRA still inhibited IL-1-induced expression of IL-6 with an efficacy similar to that of non-transfected cells (around 70%) (Figure 4b).
Negative_regulation (inhibited) of Gene_expression (expression) of IL-1 associated with agonist
18) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0 Pain Relevance 0.44
These data demonstrated that, among IL-1-activated MAPK pathways, ATRA was inhibitory only on ERK1/2 in rat synovial fibroblasts.

6.

Negative_regulation (inhibitory) of Gene_expression (pathways) of IL-1-activated in fibroblasts associated with agonist
19) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0 Pain Relevance 0.29
The combined agent (DXM+HES) reduces the levels of MDA, IL-1?
Negative_regulation (reduces) of Gene_expression (levels) of IL-1 associated with dexamethasone
20) Confidence 0.06 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2959042 Disease Relevance 1.01 Pain Relevance 0.48

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