INT195285

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.52
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Ttc21b) cilium (Ttc21b) cytoplasm (Ttc21b)
Anatomy Link Frequency
skin 2
ADF 1
neurons 1
Ttc21b (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 3 89.12 High High
Serotonin 99 80.44 Quite High
medulla 2 69.92 Quite High
Neuropeptide 15 51.40 Quite High
Deep tissue 2 45.60 Quite Low
imagery 8 44.64 Quite Low
nociceptor 3 22.56 Low Low
Neurotransmitter 9 5.00 Very Low Very Low Very Low
interneuron 6 5.00 Very Low Very Low Very Low
TRP channel 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arterial-venous Cerebral Malformations 6 98.60 Very High Very High Very High
Sprains And Strains 123 88.84 High High
Hyperoxia 333 87.76 High High
Hypoxia 18 70.08 Quite High
Death 7 61.68 Quite High
Nociception 27 26.00 Quite Low
Toxicity 10 19.92 Low Low
Stress 24 5.00 Very Low Very Low Very Low
Anorexia 18 5.00 Very Low Very Low Very Low
Cancer 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of our study demonstrate that despite the incapacity to detect QDs directly through the skin, LIF measurements allow the detection of QDs in ALN after skin incision with a profile similar to chemical extraction (Figure 4).
Gene_expression (detection) of ALN in skin
1) Confidence 0.37 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2375898 Disease Relevance 0 Pain Relevance 0.03
While QDs emission in the ALN was not detected across the skin, a clear signal was evidenced after incision of the skin and measurement on the ALN (called ALN in vivo) (Figure 4) (P = 0.0209 for 5, 15, 30 min; P = 0.0339 for 60 min and P = 0.0143 for 24 h).
Neg (not) Gene_expression (detected) of ALN in skin
2) Confidence 0.33 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2375898 Disease Relevance 0 Pain Relevance 0
URX, AQR, PQR, SDQ, ALN, and PLN express sGCs that bind to molecular oxygen, consistent with a primary oxygen-sensing function [11].
Gene_expression (express) of ALN
3) Confidence 0.01 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1540710 Disease Relevance 0.43 Pain Relevance 0
gcy-35::GFP reporter genes are expressed reliably in URX, AQR, PQR, SDQ, ALN, and BDU neurons, and variably in AVM, PLM, and PLN neurons [11,16].
Gene_expression (expressed) of ALN in neurons associated with arterial-venous cerebral malformations
4) Confidence 0.01 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1540710 Disease Relevance 0.76 Pain Relevance 0
At least four sets of sensory neurons promote avoidance of high oxygen: (1) some or all of URX, AQR, and PQR, which express multiple sGCs; (2) some or all of SDQ, ALN, and PLN, which express the sGC homolog gcy-35; and (3–4) the osm-9 (TRPV)–expressing neurons ADF and ASH (Figure 8A).
Gene_expression (express) of ALN in ADF
5) Confidence 0.01 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1540710 Disease Relevance 0.33 Pain Relevance 0.11

General Comments

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