INT195362

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Context Info
Confidence 0.09
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.33
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (AQR) nucleus (AQR)
Anatomy Link Frequency
neurons 2
AQR (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 132 95.08 Very High Very High Very High
Neurotransmitter 12 53.92 Quite High
Hippocampus 4 48.88 Quite Low
Neuropeptide 20 47.28 Quite Low
TRP channel 4 38.00 Quite Low
interneuron 8 5.00 Very Low Very Low Very Low
nociceptor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 164 99.88 Very High Very High Very High
Hyperoxia 444 99.22 Very High Very High Very High
Hypoxia 24 76.08 Quite High
Nociception 36 74.24 Quite High
Stress 32 57.32 Quite High
Infection 8 32.72 Quite Low
Fever 8 31.72 Quite Low
Anorexia 24 5.00 Very Low Very Low Very Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Arterial-venous Cerebral Malformations 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phenotypes of npr-1(lf) strains are consistent with increased URX, AQR, and PQR activity, and subsequent stimulation of both hyperoxia avoidance and aggregation on food.
Positive_regulation (increased) of AQR associated with hyperoxia and sprains and strains
1) Confidence 0.09 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1540710 Disease Relevance 0.83 Pain Relevance 0.19
tph-1 was also required for hyperoxia avoidance in the qaIs2241 strain that lacked URX, AQR, and PQR neurons, as were ocr-2 and osm-9 TRPV genes (Figure 2G–I).
Positive_regulation (lacked) of AQR in neurons associated with hyperoxia and sprains and strains
2) Confidence 0.07 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1540710 Disease Relevance 0.92 Pain Relevance 0.16
Enhanced aerotaxis activity of URX, AQR, and PQR in npr-1 mutants may relieve the requirement for gcy-34 activity.
Positive_regulation (Enhanced) of AQR
3) Confidence 0.06 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1540710 Disease Relevance 0.43 Pain Relevance 0
Animals with npr-1(215F) or npr-1(lf) alleles aggregate into feeding groups on bacterial lawns, a behavior that requires gcy-35 and gcy-36 in URX, AQR, and PQR neurons [13,16].
Positive_regulation (requires) of AQR in neurons
4) Confidence 0.06 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1540710 Disease Relevance 0.16 Pain Relevance 0

General Comments

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