INT19537

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Context Info
Confidence 0.43
First Reported 1991
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.32
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ALB) small molecule metabolic process (ALB) enzyme binding (ALB)
DNA binding (ALB) protein complex (ALB) transmembrane transport (ALB)
Anatomy Link Frequency
plasma 4
ALB (Homo sapiens)
Pain Link Frequency Relevance Heat
rapifen 9 100.00 Very High Very High Very High
anesthesia 3 99.56 Very High Very High Very High
diclofenac 2 99.50 Very High Very High Very High
ischemia 11 99.40 Very High Very High Very High
cINOD 2 99.18 Very High Very High Very High
lidocaine 1 98.16 Very High Very High Very High
cva 17 94.00 High High
butorphanol 4 92.56 High High
rheumatoid arthritis 4 92.20 High High
Analgesic 4 83.68 Quite High
Disease Link Frequency Relevance Heat
Cirrhosis 31 99.86 Very High Very High Very High
Cv General 4 Under Development 7 99.84 Very High Very High Very High
INFLAMMATION 20 99.06 Very High Very High Very High
Myocardial Infarction 49 98.60 Very High Very High Very High
Cv Unclassified Under Development 9 98.20 Very High Very High Very High
Pulmonary Embolism 10 94.00 High High
Renal Failure 18 92.40 High High
Emergencies 5 92.32 High High
Rheumatoid Arthritis 4 92.20 High High
Pressure And Volume Under Development 15 88.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In patients with cirrhosis, AAG, albumin concentrations, and alfentanil binding are decreased.
Negative_regulation (decreased) of albumin Binding (binding) of associated with rapifen and cirrhosis
1) Confidence 0.43 Published 1991 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 2071261 Disease Relevance 0.79 Pain Relevance 0.54
Non-steroidal anti-inflammatory drugs like diclofenac, ibuprofen and naproxen inhibited the aggregation of albumin at low concentrations (EC50 10(-4)-10(-5) mol/l) comparable to those active in a classical turbidimetric method, whereas the effect of weak stabilizers, like sodium cloride and formic, fumaric, maleic, malonic, and succinic acid (EC50 10(-1)-10(-2) mol/l in the Mizushima test) was not detectable.
Negative_regulation (inhibited) of albumin Binding (aggregation) of associated with inflammation, cinod and diclofenac
2) Confidence 0.43 Published 1998 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 9589803 Disease Relevance 0.38 Pain Relevance 0.35
At approximately therapeutic concentrations, the antirheumatics inhibited the formation of complexes of homologous antibodies with human serum albumin and, surprisingly, with human IgG.
Negative_regulation (inhibited) of serum albumin Binding (complexes) of
3) Confidence 0.40 Published 1995 Journal Eur J Clin Chem Clin Biochem Section Abstract Doc Link 8608192 Disease Relevance 0 Pain Relevance 0.05
Its detrimental effect on kidney function can be prevented by plasma expansion with albumin [8].
Negative_regulation (prevented) of albumin Binding (expansion) of in plasma
4) Confidence 0.40 Published 2008 Journal Crit Care Section Body Doc Link PMC2374626 Disease Relevance 0.51 Pain Relevance 0
The ability of human serum albumin to bind cobalt is reduced in myocardial ischemia [85,86].
Negative_regulation (reduced) of albumin Binding (bind) of associated with cv general 4 under development and ischemia
5) Confidence 0.26 Published 2008 Journal Crit Care Section Body Doc Link PMC2481437 Disease Relevance 1.55 Pain Relevance 0.52
Clinical pathology changes at 48 h after anesthesia and surgery included decreased hematocrit, total solids, phosphorus, total protein, albumin, globulin, potassium, and chloride and increased plasma glucose, aspartate aminotransferase, creatine kinase, and bicarbonate.
Negative_regulation (decreased) of albumin Binding (hematocrit) of in plasma associated with anesthesia
6) Confidence 0.04 Published 2005 Journal Comp. Med. Section Abstract Doc Link 16089168 Disease Relevance 0.08 Pain Relevance 0.81

General Comments

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