INT19538

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Context Info
Confidence 0.67
First Reported 1982
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 3.21
Pain Relevance 3.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MPG) nucleus (MPG) DNA binding (MPG)
Anatomy Link Frequency
plasma 1
optic 1
MPG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 99.96 Very High Very High Very High
rapifen 9 99.90 Very High Very High Very High
lidocaine 19 99.72 Very High Very High Very High
Morphine 8 99.68 Very High Very High Very High
Oxycodone 10 99.42 Very High Very High Very High
tolerance 2 99.32 Very High Very High Very High
Analgesic 1 97.96 Very High Very High Very High
epidural 2 96.56 Very High Very High Very High
Perioperative pain 1 94.76 High High
rheumatoid arthritis 2 94.72 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 5 99.96 Very High Very High Very High
Cancer 5 99.90 Very High Very High Very High
Diabetes Mellitus-type I 3 99.08 Very High Very High Very High
Renal Failure 2 95.76 Very High Very High Very High
Cirrhosis 2 95.16 Very High Very High Very High
Post Operative Pain 1 94.76 High High
Rheumatoid Arthritis 2 94.72 High High
Disease 33 94.16 High High
Malignant Neoplastic Disease 2 93.84 High High
Myocardial Infarction 3 93.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this study was to determine the relationship between inflammation, increased alpha-1-acid glycoprotein (AAG), and lidocaine tolerance during fiber-optic bronchoscopy.
Positive_regulation (increased) of AAG in optic associated with inflammation, tolerance and lidocaine
1) Confidence 0.67 Published 1987 Journal Respiration Section Abstract Doc Link 3563124 Disease Relevance 0.37 Pain Relevance 0.77
In addition, bound fractions of oxycodone and morphine increased with increasing concentrations of both albumin and AAG.
Positive_regulation (increasing) of AAG associated with oxycodone and morphine
2) Confidence 0.67 Published 1993 Journal Ther Drug Monit Section Abstract Doc Link 8249052 Disease Relevance 0 Pain Relevance 1.32
Binding of alfentanil was measured in human alpha 1-acid glycoprotein (AAG) and human albumin solutions, and in serum from 6 groups of individuals: control subjects, patients with renal failure, cirrhosis, rheumatoid arthritis and myocardial infarction, and intensive care patients.
Positive_regulation (measured) of AAG associated with rapifen, cirrhosis, renal failure, rheumatoid arthritis and myocardial infarction
3) Confidence 0.49 Published 1991 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 2071261 Disease Relevance 0.63 Pain Relevance 0.38
Patients with cancer had increased serum concentrations of the acute-phase protein alpha 1-acid glycoprotein (AAG) and lowered serum concentration of albumin.
Positive_regulation (increased) of AAG associated with cancer
4) Confidence 0.49 Published 1982 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 7105620 Disease Relevance 0.47 Pain Relevance 0.27
This group had lower concentrations of both albumin and alpha 1-acid glycoprotein (AAG), achieving statistical significance vs control for albumin only.
Positive_regulation (concentrations) of AAG
5) Confidence 0.49 Published 1993 Journal Clin Pharmacokinet Section Abstract Doc Link 8453825 Disease Relevance 0.62 Pain Relevance 0.43
This study examined the effect of postoperative increases (in response to surgery) in plasma alpha1-acid-glycoprotein (AAG) concentrations on the plasma concentrations of the enantiomers of bupivacaine during continuous epidural infusion of racemic bupivacaine for postoperative pain relief.
Spec (examined) Positive_regulation (increases) of AAG in plasma associated with epidural and perioperative pain
6) Confidence 0.49 Published 2002 Journal Anesthesiology Section Abstract Doc Link 11981143 Disease Relevance 0.09 Pain Relevance 0.18
This study aimed to determine the effects of phototherapy induced DNA damage and activation of the DNA repair gene methylpurine DNA glycosylase (MPG).
Positive_regulation (activation) of DNA repair gene methylpurine DNA glycosylase
7) Confidence 0.46 Published 2009 Journal J. Photochem. Photobiol. B, Biol. Section Abstract Doc Link 19101162 Disease Relevance 0.36 Pain Relevance 0.09
This study aimed to determine the effects of phototherapy induced DNA damage and activation of the DNA repair gene methylpurine DNA glycosylase (MPG).
Positive_regulation (activation) of MPG
8) Confidence 0.46 Published 2009 Journal J. Photochem. Photobiol. B, Biol. Section Abstract Doc Link 19101162 Disease Relevance 0.36 Pain Relevance 0.09
Gender inequalities were identified as a major barrier towards achieving MDG in LAC countries.
Positive_regulation (achieving) of MDG
9) Confidence 0.10 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898047 Disease Relevance 0.30 Pain Relevance 0.04

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