INT19539

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 15
Disease Relevance 9.40
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ADRA1D) plasma membrane (ADRA1D) cell-cell signaling (ADRA1D)
DNA metabolic process (ADRA1D) signal transducer activity (ADRA1D)
Anatomy Link Frequency
plasma 2
bile duct 2
gland 2
ADRA1D (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 162 100.00 Very High Very High Very High
rapifen 20 100.00 Very High Very High Very High
Bile 7 99.70 Very High Very High Very High
Cluster headache 6 99.70 Very High Very High Very High
Opioid 2 99.60 Very High Very High Very High
Dismenorea 2 98.96 Very High Very High Very High
Analgesic 1 97.96 Very High Very High Very High
Inflammation 1 97.68 Very High Very High Very High
Pain 3 97.22 Very High Very High Very High
rheumatoid arthritis 2 95.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hematuria 42 100.00 Very High Very High Very High
Pancreatic Cancer 46 99.84 Very High Very High Very High
Cluster Headache 6 99.70 Very High Very High Very High
Benign Prostatic Hypertrophy 606 99.38 Very High Very High Very High
Dysmenorrhea 2 98.96 Very High Very High Very High
INFLAMMATION 1 97.68 Very High Very High Very High
Pain 2 97.22 Very High Very High Very High
Renal Failure 2 96.92 Very High Very High Very High
Cirrhosis 2 96.32 Very High Very High Very High
Cancer 28 95.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effective mechanism of phenylephrine might involve the increased expression of alpha1-AR, translocation of AQP(5) from cytoplasm to apical membrane, activation of signal molecules related to cell proliferation, and moderate the atrophy of the gland.
Positive_regulation (increased) of Gene_expression (expression) of alpha1 in gland associated with frailty
1) Confidence 0.67 Published 2007 Journal Beijing Da Xue Xue Bao Section Abstract Doc Link 17304317 Disease Relevance 0.09 Pain Relevance 0.08
Binding of alfentanil was measured in human alpha 1-acid glycoprotein (AAG) and human albumin solutions, and in serum from 6 groups of individuals: control subjects, patients with renal failure, cirrhosis, rheumatoid arthritis and myocardial infarction, and intensive care patients.
Positive_regulation (measured) of Gene_expression (solutions) of alpha 1 associated with rapifen, cirrhosis, renal failure, rheumatoid arthritis and myocardial infarction
2) Confidence 0.49 Published 1991 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 2071261 Disease Relevance 0.70 Pain Relevance 0.39
Cotransfection of TR alpha 1 along with ER alpha inhibited the ER alpha transactivation of PPE by approximately 50%.
Positive_regulation (Cotransfection) of Gene_expression (Cotransfection) of alpha 1
3) Confidence 0.49 Published 2001 Journal J. Neuroendocrinol. Section Abstract Doc Link 11578528 Disease Relevance 0.08 Pain Relevance 0
Compared to the pre-CPB period as well as to patients not exposed to CPB, CABG patients after CPB exhibited an increased elimination half-time (t1/2 beta = 180 +/- 55 min SD), central distribution volume (Vc = 0.25 +/- 0.07 L/kg), and total volume of distribution (Vdss 0.63 +/- 0.08 L/kg; Vd area 0.92 +/- 0.23 L/kg) which reflected a 33%-50% decrease in alpha 1-acid glycoprotein, the principal plasma protein to which alfentanil is bound.
Positive_regulation (principal) of Gene_expression (bound) of alpha 1 in plasma associated with rapifen
4) Confidence 0.49 Published 1994 Journal Anesth. Analg. Section Abstract Doc Link 8311274 Disease Relevance 0 Pain Relevance 0.49
We have thus concluded that bile duct ligation induces a defect in the functional expression of cardiovascular alpha 1-adrenoceptors without any effects on the activity of alpha 2-adrenoceptors or norepinephrine uptake.
Positive_regulation (induces) of Gene_expression (expression) of alpha 1 in bile duct associated with bile
5) Confidence 0.49 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8105696 Disease Relevance 0.07 Pain Relevance 0.51
Low titers of antibody response in the pain free periods of these subjects, and high titers in the painful periods has also been found in the serum of cluster headache patients; the lack of alpha 1-antitrypsin in basal conditions; increase of IgE (PRIST) values in painful periods; high titers of C1qSp and KgBt circulating immuno-complexes.
Positive_regulation (increase) of Neg (lack) Gene_expression (lack) of alpha 1 associated with cluster headache, pain and dismenorea
6) Confidence 0.49 Published 1990 Journal Ann. Ital. Med. Int. Section Abstract Doc Link 2150489 Disease Relevance 1.09 Pain Relevance 0.88
Recent studies demonstrate that 5-alpha-reductase inhibitors are effective in the treatment of BPH-induced hematuria,41 probably through their effect on prostate microvessel density.42 Multiple studies now support the role of short-term 5-alpha-reductase inhibitor monotherapy prior to definitive surgical resection in order to decrease hematuria during and after the procedure.43,44

5-alpha-reductase inhibitor and alpha-adrenergic receptor antagonist combination therapy

Positive_regulation (prior) of Gene_expression (therapy) of alpha-adrenergic receptor associated with benign prostatic hypertrophy, antagonist and hematuria
7) Confidence 0.34 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778433 Disease Relevance 0.99 Pain Relevance 0.05
Recent studies demonstrate that 5-alpha-reductase inhibitors are effective in the treatment of BPH-induced hematuria,41 probably through their effect on prostate microvessel density.42 Multiple studies now support the role of short-term 5-alpha-reductase inhibitor monotherapy prior to definitive surgical resection in order to decrease hematuria during and after the procedure.43,44

5-alpha-reductase inhibitor and alpha-adrenergic receptor antagonist combination therapy

Positive_regulation (hematuria) of Gene_expression (therapy) of alpha-adrenergic receptor associated with benign prostatic hypertrophy, antagonist and hematuria
8) Confidence 0.34 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778433 Disease Relevance 0.96 Pain Relevance 0.05
Recent studies demonstrate that 5-alpha-reductase inhibitors are effective in the treatment of BPH-induced hematuria,41 probably through their effect on prostate microvessel density.42 Multiple studies now support the role of short-term 5-alpha-reductase inhibitor monotherapy prior to definitive surgical resection in order to decrease hematuria during and after the procedure.43,44

5-alpha-reductase inhibitor and alpha-adrenergic receptor antagonist combination therapy

Positive_regulation (-) of Gene_expression (therapy) of alpha-adrenergic receptor associated with benign prostatic hypertrophy, antagonist and hematuria
9) Confidence 0.34 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778433 Disease Relevance 1.00 Pain Relevance 0.05
Recent studies demonstrate that 5-alpha-reductase inhibitors are effective in the treatment of BPH-induced hematuria,41 probably through their effect on prostate microvessel density.42 Multiple studies now support the role of short-term 5-alpha-reductase inhibitor monotherapy prior to definitive surgical resection in order to decrease hematuria during and after the procedure.43,44

5-alpha-reductase inhibitor and alpha-adrenergic receptor antagonist combination therapy

Positive_regulation (after) of Gene_expression (therapy) of alpha-adrenergic receptor associated with benign prostatic hypertrophy, antagonist and hematuria
10) Confidence 0.34 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778433 Disease Relevance 0.91 Pain Relevance 0.05
Recent studies demonstrate that 5-alpha-reductase inhibitors are effective in the treatment of BPH-induced hematuria,41 probably through their effect on prostate microvessel density.42 Multiple studies now support the role of short-term 5-alpha-reductase inhibitor monotherapy prior to definitive surgical resection in order to decrease hematuria during and after the procedure.43,44

5-alpha-reductase inhibitor and alpha-adrenergic receptor antagonist combination therapy

Positive_regulation (through) of Gene_expression (therapy) of alpha-adrenergic receptor associated with benign prostatic hypertrophy, antagonist and hematuria
11) Confidence 0.34 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778433 Disease Relevance 1.19 Pain Relevance 0.05
Recent studies demonstrate that 5-alpha-reductase inhibitors are effective in the treatment of BPH-induced hematuria,41 probably through their effect on prostate microvessel density.42 Multiple studies now support the role of short-term 5-alpha-reductase inhibitor monotherapy prior to definitive surgical resection in order to decrease hematuria during and after the procedure.43,44

5-alpha-reductase inhibitor and alpha-adrenergic receptor antagonist combination therapy

Positive_regulation (during) of Gene_expression (therapy) of alpha-adrenergic receptor associated with benign prostatic hypertrophy, antagonist and hematuria
12) Confidence 0.34 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778433 Disease Relevance 0.91 Pain Relevance 0.05
Concomitant with an enhanced expression of mu-opioid binding sites, the levels of the inhibitory G proteins Gi alpha 1 and Gi alpha 2 were found to be significantly increased.
Positive_regulation (increased) of Gene_expression (levels) of Gi alpha 1 associated with opioid
13) Confidence 0.06 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8133263 Disease Relevance 0.25 Pain Relevance 0.15
A number of proteins important for the formation of adherens junctions, such as vinculin, alpha 1 actinin and poliovirus receptor-related 1 protein were found to be overexpressed in pancreatic cancer serum.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of alpha 1 associated with pancreatic cancer
14) Confidence 0.03 Published 2009 Journal Journal of Proteome Research Section Body Doc Link PMC2652408 Disease Relevance 1.15 Pain Relevance 0.05
[The effect of oxytocin stimulation on PGE2, 6keto PGF1 alpha production in human myometrial monolayer culture].
Positive_regulation (6keto) of Gene_expression (production) of PGF1 alpha
15) Confidence 0.02 Published 1993 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Title Doc Link 8315315 Disease Relevance 0 Pain Relevance 0.06

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