INT195413

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.39
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (ALOX5AP) endoplasmic reticulum (ALOX5AP) nucleus (ALOX5AP)
enzyme binding (ALOX5AP)
Anatomy Link Frequency
vesicle 1
ALOX5AP (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 28 97.52 Very High Very High Very High
Inflammation 41 87.92 High High
Osteoarthritis 44 37.52 Quite Low
imagery 5 37.48 Quite Low
metalloproteinase 7 25.28 Quite Low
Bioavailability 2 20.72 Low Low
Multiple sclerosis 1 11.36 Low Low
agonist 28 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 94 92.40 High High
INFLAMMATION 45 87.92 High High
Anaphylactic Hypersensitivity 2 86.56 High High
Hypersensitivity 23 85.76 High High
Asthma 5 84.00 Quite High
Cancer 87 58.56 Quite High
Osteoarthritis 48 50.00 Quite Low
Skin Cancer 1 34.56 Quite Low
Pancreatic Cancer 68 33.20 Quite Low
Metastasis 14 31.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, the filtration degree (percentage of peptides denied to entering the FLAP set) of fungi allergens increased with 9% when these sequences were included, as compared to a set based on the human proteome only (data not shown).
Negative_regulation (entering) of FLAP
1) Confidence 0.37 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1540723 Disease Relevance 0.11 Pain Relevance 0
1 antibody to cultured cells attenuated HNE-induced 5-LOX and FLAP by 40% (both P < 0.05).
Negative_regulation (attenuated) of FLAP
2) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0 Pain Relevance 0
expended by the pharmaceutical industry to produce inhibitors of FLAP, 5-LOX as
Negative_regulation (inhibitors) of FLAP
3) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2631651 Disease Relevance 0.53 Pain Relevance 0.16
formation is via blocking FLAP activity, thus preventing cytoplasmic to
Negative_regulation (blocking) of FLAP
4) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2631651 Disease Relevance 0.46 Pain Relevance 0.21
In activated regions of the cell, a majority of the activated Rab7 is membrane-bound and thus the fluorescence loss after photoactivation (FLAP) specifically measures the rate of extraction of Rab7 from its target vesicle membranes.
Negative_regulation (loss) of FLAP in vesicle
5) Confidence 0.07 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.29 Pain Relevance 0

General Comments

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