INT195415

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 6.43
Pain Relevance 3.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (ALOX5AP) endoplasmic reticulum (ALOX5AP) nucleus (ALOX5AP)
enzyme binding (ALOX5AP)
Anatomy Link Frequency
osteoblasts 12
ALOX5AP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 972 100.00 Very High Very High Very High
Pain 19 75.76 Quite High
cINOD 70 70.88 Quite High
Inflammation 91 67.48 Quite High
COX-2 inhibitor 30 62.92 Quite High
Inflammatory response 14 58.72 Quite High
Inflammatory mediators 4 53.44 Quite High
Arthritis 6 46.24 Quite Low
metalloproteinase 21 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 992 100.00 Very High Very High Very High
Osteoporosis 40 80.64 Quite High
Pain 19 75.76 Quite High
INFLAMMATION 131 67.48 Quite High
Hypersensitivity 21 63.68 Quite High
Hypercalcemia 40 60.44 Quite High
Sclerosis 16 48.56 Quite Low
Arthritis 6 46.24 Quite Low
Osteophyte 19 28.44 Quite Low
Disease 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As revealed by results listed in Table 2, the lowest limit for FLAP length lies in a narrow (four amino acids) range of ?
Regulation (limit) of Gene_expression (length) of FLAP
1) Confidence 0.45 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1540723 Disease Relevance 0.06 Pain Relevance 0
indicate that the production of LTB4 is more sensitive to 1,25(OH)2D3 treatment through its effect on FLAP expression, especially in the high OA osteoblasts group, whereas the production of PGE2 is sensitive to TGF-?
Regulation (effect) of Gene_expression (expression) of FLAP in osteoblasts associated with osteoarthritis
2) Confidence 0.40 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.60 Pain Relevance 0.26
The modulation of LTB4 production in OA osteoblasts was also linked to alterations of FLAP expression in these cells in response to 1,25(OH)2D3 and TGF-?
Regulation (alterations) of Gene_expression (expression) of FLAP in osteoblasts associated with osteoarthritis
3) Confidence 0.40 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.55 Pain Relevance 0.24
Several investigations have shown that 5-LOX and FLAP expression is regulated by PGE2 [28,42].
Regulation (regulated) of Gene_expression (expression) of FLAP
4) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.08 Pain Relevance 0.04
To determine whether augmented LTB4 production induced by HNE is related to 5-LOX and FLAP synthesis, we further examined the effect of HNE on their mRNA expression.
Spec (whether) Regulation (related) of Gene_expression (synthesis) of FLAP
5) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.36 Pain Relevance 0.18
indicate that the production of LTB4 is more sensitive to 1,25(OH)2D3 treatment through its effect on FLAP expression, especially in the high OA osteoblasts group, whereas the production of PGE2 is sensitive to TGF-?
Regulation (effect) of Gene_expression (expression) of FLAP in osteoblasts associated with osteoarthritis
6) Confidence 0.29 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.60 Pain Relevance 0.26
PGE2 inhibition regulates 5-LOX and FLAP expression differentially.
Regulation (regulates) of Gene_expression (expression) of FLAP
7) Confidence 0.19 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.20 Pain Relevance 0.10
or a combination of the two because both factors have been shown to modulate the activity and/or expression of FLAP in other cell systems [28,30,31,44-46].
Regulation (modulate) of Gene_expression (expression) of FLAP
8) Confidence 0.17 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.58 Pain Relevance 0.32
It also revealed new and unique mechanisms of regulation of FLAP expression in OA osteoblasts.
Regulation (regulation) of Gene_expression (expression) of FLAP in osteoblasts associated with osteoarthritis
9) Confidence 0.17 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.64 Pain Relevance 0.43
We have shown that in OA osteoblasts the synthesis of LTs is linked to the tight regulation of FLAP expression, not that of 5-LO.
Regulation (regulation) of Gene_expression (expression) of FLAP in osteoblasts associated with osteoarthritis
10) Confidence 0.17 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.95 Pain Relevance 0.42
The expression of FLAP in OA osteoblasts is also modulated differently by 1,25(OH)2D3 and TGF-?
Regulation (modulated) of Gene_expression (expression) of FLAP in osteoblasts associated with osteoarthritis
11) Confidence 0.17 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1794527 Disease Relevance 0.89 Pain Relevance 0.37
modulated the expression of FLAP and thereby that of LTB4.
Regulation (modulated) of Gene_expression (expression) of FLAP
12) Confidence 0.17 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.90 Pain Relevance 0.51

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