INT195416

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Context Info
Confidence 0.53
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.80
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (ALOX5AP) endoplasmic reticulum (ALOX5AP) nucleus (ALOX5AP)
enzyme binding (ALOX5AP)
Anatomy Link Frequency
chondrocytes 1
ALOX5AP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 176 99.60 Very High Very High Very High
Inflammation 68 72.48 Quite High
cytokine 13 67.16 Quite High
Inflammatory response 8 49.52 Quite Low
Inflammatory mediators 5 44.24 Quite Low
Arthritis 8 37.04 Quite Low
Pain 4 26.00 Quite Low
cINOD 8 21.84 Low Low
Multiple sclerosis 1 15.72 Low Low
alcohol 4 15.00 Low Low
Disease Link Frequency Relevance Heat
Osteoarthritis 192 99.60 Very High Very High Very High
INFLAMMATION 89 72.48 Quite High
Hypersensitivity 21 59.40 Quite High
Skin Cancer 1 38.92 Quite Low
Arthritis 8 37.04 Quite Low
Pain 4 26.00 Quite Low
Systemic Lupus Erythematosus 1 16.48 Low Low
Demyelinating Disease 1 15.72 Low Low
Autoimmune Disease 1 14.44 Low Low
Disease 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although sequences from the three additional proteomes represent a very small fraction relative to the human counterpart their presence markedly affected the FLAP extraction procedure.
Regulation (affected) of FLAP
1) Confidence 0.53 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1540723 Disease Relevance 0.12 Pain Relevance 0
Thereafter, we explored 5-LOX and FLAP regulation in human OA chondrocytes by HNE, examined the relative involvement of these two proteins in LTB4 production, and studied the factors that might be responsible for enhanced LTB4 production in these cells incubated for long periods.
Spec (examined) Regulation (regulation) of FLAP in chondrocytes associated with osteoarthritis
2) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.19 Pain Relevance 0.13
5-LOX and FLAP are essential proteins responsible for LTB4 synthesis.
Regulation (responsible) of FLAP
3) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.35 Pain Relevance 0.18
These data confirm that LTB4 production is dependent on the regulation of both 5-LOX and FLAP.
Regulation (regulation) of FLAP
4) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.06 Pain Relevance 0.03
Several investigations have shown that 5-LOX and FLAP expression is regulated by PGE2 [28,42].
Regulation (regulated) of FLAP
5) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.08 Pain Relevance 0.04

General Comments

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