INT195421

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.17
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (ALOX5AP) endoplasmic reticulum (ALOX5AP) nucleus (ALOX5AP)
enzyme binding (ALOX5AP)
Anatomy Link Frequency
osteoblasts 4
chondrocytes 2
ALOX5AP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 657 99.64 Very High Very High Very High
antagonist 14 97.52 Very High Very High Very High
cINOD 46 92.24 High High
Inflammation 106 88.48 High High
COX-2 inhibitor 21 86.72 High High
Inflammatory response 12 72.76 Quite High
Pain 15 70.36 Quite High
cytokine 11 46.12 Quite Low
metalloproteinase 21 5.00 Very Low Very Low Very Low
agonist 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 674 99.64 Very High Very High Very High
Calcification 12 97.08 Very High Very High Very High
Atherosclerosis 44 88.68 High High
INFLAMMATION 136 88.48 High High
Anaphylactic Hypersensitivity 1 86.56 High High
Hypersensitivity 22 85.76 High High
Osteoporosis 25 82.16 Quite High
Asthma 3 81.84 Quite High
Myalgia 1 70.36 Quite High
Cancer 46 60.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Parameter evaluation and the resulting FLAP set
Positive_regulation (resulting) of Gene_expression (set) of FLAP
1) Confidence 0.49 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1540723 Disease Relevance 0 Pain Relevance 0
FLAP expression is activated earlier than 5-LOX, which occurs only after 48 hours of HNE stimulation.
Positive_regulation (activated) of Gene_expression (expression) of FLAP
2) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.15 Pain Relevance 0.08
The following 5 genes were significantly upregulated: ALOX5AP (+3.6-fold, p?
Positive_regulation (upregulated) of Gene_expression (fold) of ALOX5AP
3) Confidence 0.46 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762369 Disease Relevance 0.07 Pain Relevance 0.07
In fact, the increase in LTB4 was either due to an upregulation of FLAP expression in high OA osteoblasts in response to inhibitors of PGE2 production or it was already high in the low OA subgroup.
Positive_regulation (upregulation) of Gene_expression (expression) of FLAP in osteoblasts associated with osteoarthritis
4) Confidence 0.45 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.98 Pain Relevance 0.78
was able to stimulate FLAP expression to the levels observed in normal cells under similar conditions.
Positive_regulation (stimulate) of Gene_expression (expression) of FLAP
5) Confidence 0.45 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.57 Pain Relevance 0.25
Furthermore, this elevated FLAP expression could be curbed by exogenous PGE2.
Positive_regulation (elevated) of Gene_expression (expression) of FLAP
6) Confidence 0.45 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.93 Pain Relevance 0.64
Four lipoxygenase pathway variants contributed to variation in CorCP—one in ALOX5 (rs2115819), one in ALOX12 (rs2271316), and two in ALOX5AP (rs9506352 and rs4769060).
Positive_regulation (variation) of Gene_expression (two) of ALOX5AP
7) Confidence 0.43 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0.43 Pain Relevance 0
The FLAP mRNA level was significantly enhanced after a short period (20 hours) of treatment with TGF-?
Positive_regulation (enhanced) of Gene_expression (level) of FLAP mRNA
8) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.13 Pain Relevance 0.06
1 production could be involved in HNE-induced 5-LOX and FLAP expression, chondrocytes were treated or not with a single addition of 10 ?
Positive_regulation (involved) of Gene_expression (expression) of FLAP in chondrocytes
9) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.05 Pain Relevance 0.03
This shunt was either related to an increase in 5-LO expression or that of FLAP through an IL-10-dependent or IL-18-dependent pathway in other cell systems.
Positive_regulation (increase) of Gene_expression (expression) of FLAP
10) Confidence 0.32 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.61 Pain Relevance 0.36
Such an increase in FLAP expression in response to NS-398 could explain our previous observation of an increase in LTB4 production by OA osteoblasts under similar conditions [12].
Positive_regulation (increase) of Gene_expression (expression) of FLAP in osteoblasts associated with osteoarthritis
11) Confidence 0.30 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.71 Pain Relevance 0.40
expended by the pharmaceutical industry to produce inhibitors of FLAP, 5-LOX as
Positive_regulation (expended) of Gene_expression (produce) of FLAP
12) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2631651 Disease Relevance 0.53 Pain Relevance 0.16

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