INT195439

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.53
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp13) extracellular space (Mmp13) extracellular region (Mmp13)
Golgi apparatus (Mmp13) proteinaceous extracellular matrix (Mmp13) lysosome (Mmp13)
Anatomy Link Frequency
chondrocytes 2
Mmp13 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1 98.28 Very High Very High Very High
ischemia 21 92.16 High High
Inflammation 4 66.72 Quite High
metalloproteinase 2 50.00 Quite Low
cva 3 9.52 Low Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1 98.28 Very High Very High Very High
Cv General 4 Under Development 5 92.52 High High
Brain Injury 4 75.68 Quite High
Cv Unclassified Under Development 15 74.96 Quite High
INFLAMMATION 4 66.72 Quite High
Apoptosis 3 64.96 Quite High
Stroke 25 49.44 Quite Low
Death 2 35.28 Quite Low
Reperfusion Injury 1 32.64 Quite Low
Pressure And Volume Under Development 2 25.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies, however, have shown that multiple tetracyclines can inhibit collagenase MMPs via down-regulation of gene expression in a cellular model of rheumatoid arthritis using cultured chondrocytes [33] and that pre-treatment with minocycline down-regulates pro-MMP expression after permanent cerebral ischemia [17].
Negative_regulation (inhibit) of Regulation (regulation) of collagenase in chondrocytes associated with cv general 4 under development, ischemia and rheumatoid arthritis
1) Confidence 0.41 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1543649 Disease Relevance 0.53 Pain Relevance 0.20

General Comments

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