INT195443

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.95
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP2, Mmp9) extracellular space (MMP2, Mmp9) extracellular region (MMP2, Mmp9)
proteinaceous extracellular matrix (MMP2, Mmp9) aging (Mmp9) plasma membrane (MMP2)
Anatomy Link Frequency
brain 2
MMP2 (Homo sapiens)
Mmp9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 21 99.68 Very High Very High Very High
Inflammation 4 86.76 High High
metalloproteinase 2 50.00 Quite Low
cva 3 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 15 99.68 Very High Very High Very High
Death 2 97.96 Very High Very High Very High
Pressure And Volume Under Development 2 96.88 Very High Very High Very High
Brain Injury 4 92.84 High High
INFLAMMATION 4 86.76 High High
Stroke 25 85.32 High High
Injury 1 77.16 Quite High
Cv General 4 Under Development 5 16.08 Low Low
Hemorrhage 4 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since MMP-2 and MMP-9 are believed to be largely responsible for the degradation of the blood brain barrier and also involved in the signaling of neuronal cell death [24,25], the inhibition of the proteolytic cascade is a logical target for several models of brain injury that involve matrix degradation and vascular instability [26].
MMP-2 Positive_regulation (responsible) of Protein_catabolism (degradation) of MMP-9 in brain associated with brain injury and death
1) Confidence 0.15 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1543649 Disease Relevance 0.95 Pain Relevance 0.14

General Comments

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