INT195449

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.38
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SAT1) small molecule metabolic process (SAT1) intracellular (SAT1)
transferase activity, transferring acyl groups (SAT1) cellular nitrogen compound metabolic process (SAT1) cytoplasm (SAT1)
SAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 1 82.00 Quite High
Inflammation 37 63.00 Quite High
Ultiva 1 50.72 Quite High
cytokine 15 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 4 99.90 Very High Very High Very High
Breast Cancer 4 97.88 Very High Very High Very High
Colorectal Cancer 92 97.04 Very High Very High Very High
Cancer 108 90.88 High High
Colon Cancer 12 79.60 Quite High
Carcinoma 4 70.40 Quite High
Injury 30 69.32 Quite High
Adenocarcinoma 8 63.68 Quite High
INFLAMMATION 33 63.00 Quite High
Lung Injury 18 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
could increase SSAT expression in these cells [15].
Positive_regulation (increase) of Gene_expression (expression) of SSAT
1) Confidence 0.69 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.47 Pain Relevance 0
induces SSAT expression and influences polyamine availability, regulating cell proliferation and differentiation.
Positive_regulation (induces) of Gene_expression (expression) of SSAT
2) Confidence 0.69 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.46 Pain Relevance 0
restored the SSAT promoter activity, and an activated PPAR?
Positive_regulation (activated) of Gene_expression (activity) of SSAT promoter
3) Confidence 0.50 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.48 Pain Relevance 0
On the other hand, in prostatic cancer the SSAT overexpression induces growth inhibition without determining polyamine pool depletion since SSAT activity seems to modulate ODC activity [11,34].
Positive_regulation (overexpression) of Gene_expression (overexpression) of SSAT associated with prostate cancer
4) Confidence 0.50 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.79 Pain Relevance 0
Sat PC was recovered after treatment of organic solvet extracts of the BALF with osmium tetroxide by alumina column chromatography and quantified by phosphorus assay [20].
Positive_regulation (recovered) of Gene_expression (recovered) of Sat PC
5) Confidence 0.13 Published 2010 Journal Respir Res Section Body Doc Link PMC2978154 Disease Relevance 0.20 Pain Relevance 0.12

General Comments

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