INT195521

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.51
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm2) plasma membrane (Grm2) intracellular (Grm2)
signal transducer activity (Grm2)
Grm2 (Mus musculus)
Pain Link Frequency Relevance Heat
hyperexcitability 1 98.88 Very High Very High Very High
Spinal cord 4 94.32 High High
Dorsal horn 6 93.56 High High
Glutamate 17 92.24 High High
Neurotransmitter 7 89.40 High High
Glutamate receptor 11 77.76 Quite High
Lamotrigine 4 70.52 Quite High
sSRI 34 64.12 Quite High
Analgesic 5 50.00 Quite Low
nMDA receptor 13 35.12 Quite Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 209 96.88 Very High Very High Very High
Manic Depressive Disorder 3 56.16 Quite High
Epilepsy 2 55.32 Quite High
Obsessive-compulsive Disorder 12 5.00 Very Low Very Low Very Low
Cognitive Disorder 9 5.00 Very Low Very Low Very Low
Tourette's Syndrome 9 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 9 5.00 Very Low Very Low Very Low
Congenital Anomalies 7 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M) to the cultures had no effect on the transcript of mGlu2 or mGlu3 at any time points (not shown).


Neg (no) Regulation (effect) of mGlu2
1) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0 Pain Relevance 0.09
Two agents aimed at modulating mGluR2 function by distinct routes have recently been proposed for the treatment of OCD.
Regulation (modulating) of mGluR2 associated with anxiety disorder
2) Confidence 0.01 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.51 Pain Relevance 0.52

General Comments

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