INT195527

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 4.42
Pain Relevance 3.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rela) nucleus (Rela) DNA binding (Rela)
protein complex (Rela) transcription factor binding (Rela) cytoplasm (Rela)
Anatomy Link Frequency
nucleus 3
astrocytes 2
microglia 2
neuronal 1
Lung 1
Rela (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 74 100.00 Very High Very High Very High
cva 12 99.82 Very High Very High Very High
Inflammation 361 97.72 Very High Very High Very High
Morphine 234 97.64 Very High Very High Very High
cytokine 260 91.52 High High
agonist 11 71.96 Quite High
Neurotransmitter 3 71.44 Quite High
metalloproteinase 1 69.00 Quite High
chemokine 43 68.20 Quite High
Inflammatory mediators 9 67.84 Quite High
Disease Link Frequency Relevance Heat
Hemorrhage 17 99.82 Very High Very High Very High
Reperfusion Injury 20 99.76 Very High Very High Very High
Apoptosis 67 99.12 Very High Very High Very High
Parkinson's Disease 24 98.96 Very High Very High Very High
INFLAMMATION 374 97.72 Very High Very High Very High
Neurodegenerative Disease 23 97.68 Very High Very High Very High
Skin Cancer 14 95.28 Very High Very High Very High
Disease 75 94.44 High High
Shock 41 91.60 High High
Stress 39 90.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The proportion of astrocytes stained with p65 (RelA)-immunoreactive nuclei was then determined.
p65 Binding (stained) of in astrocytes
1) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.83
B (p50/p65), p50 homodimer, and c-Rel DNA binding activity compared to cells that lacked the inhibitor.
p65 Binding (binding) of
2) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.44
The proportion of astrocytes stained with p65 (RelA)-immunoreactive nuclei was then determined.
RelA Binding (stained) of in astrocytes
3) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.83
B p65 and p50 mRNA in the SN compared with wild-type AAV2-GFP treated mice.
p65 Binding (compared) of associated with substantia nigra
4) Confidence 0.23 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.20 Pain Relevance 0.16
In MPTP treated mice, there is also marked accumulation of p65 in microglia, and activation of NF-?
p65 Binding (microglia) of in microglia associated with parkinson's disease
5) Confidence 0.23 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.50 Pain Relevance 0.19
B p65-p50 heterodimers enter the nucleus, bind to NF-?
p65 Binding (bind) of in nucleus
6) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.47 Pain Relevance 0.33
Following 24 hours of challenge, 106 cells from both groups were frozen for ChIP-Q-PCR and shipped to Genpathway [79] for querying the chromatin for detection and quantification of p65 binding upstream of specific genes using chromatin immunopreciptation (ChIP) combined with real time PCR (Q-PCR) (Genpathway's FactorPath Query assay) [80].
p65 Binding (binding) of
7) Confidence 0.10 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.11 Pain Relevance 0
B binding activity, and nuclear p65/p50 levels).
p65 Binding (binding) of
8) Confidence 0.09 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2668769 Disease Relevance 0.65 Pain Relevance 0.05
B subunit p65 and p50, and Lamin B.
p65 Binding (subunit) of
9) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0 Pain Relevance 0
Interestingly, the transcriptional activity of p65/Rel-A is regulated by acetylation, and p300 itself is endowed with acetyltransferase activity [20-23].
p65 Binding (activity) of
10) Confidence 0.09 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0 Pain Relevance 0
Target validation was sought for genes known to have a binding site for NF-kappaB p65.
p65 Binding (binding) of
11) Confidence 0.09 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.14 Pain Relevance 0
degradation or NFkB DNA binding in brain microglia, implicating that luteolin-mediated effects in microglia are not solely dependent on NFkB blockade [34].
NFkB Binding (binding) of in microglia
12) Confidence 0.05 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0.23 Pain Relevance 0.16
The association of p65 NF-?
p65 Binding (association) of
13) Confidence 0.04 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.48 Pain Relevance 0.08
These data are supported by the findings of Shenkar et al., who similarly demonstrated that inhibition of xanthine oxidase and production of reactive oxygen species in mice before hemorrhage reduced interactions between p65 and CBP, while CREB-CBP associations were significantly increased.11
p65 Binding (interactions) of associated with cva
14) Confidence 0.04 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.51 Pain Relevance 0.25
Once in the nucleus, the p65 subunit is phosphorylated at serine 276, which enhances its ability to recruit CBP and p300 and subsequently bind to DNA.36,37 Here, HSPTX-resuscitated animals displayed a marked reduction in nuclear phosphorylated NF-?
p65 Binding (recruit) of in nucleus
15) Confidence 0.04 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.37 Pain Relevance 0.12
Interactions between CBP and CREB or p65 were demonstrated with a modification of the method reported by Gerritsen and coworkers.21 Lung nuclear extracts (10 ?
p65 Binding (Interactions) of in Lung
16) Confidence 0.04 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0 Pain Relevance 0
Once in the nucleus, the p65 subunit is phosphorylated at serine 276, which enhances its ability to recruit CBP and p300 and subsequently bind to DNA.36,37 Here, HSPTX-resuscitated animals displayed a marked reduction in nuclear phosphorylated NF-?
p65 Binding (ability) of in nucleus
17) Confidence 0.04 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.37 Pain Relevance 0.12
Association between SIRT1 and p53, p65, c-jun and E2F1, all of which are involved in regulating neuronal apoptosis, has previously been reported (reviewed in [1]; [55], [64]–[66]).
p65 Binding (Association) of in neuronal associated with neurodegenerative disease
18) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.39 Pain Relevance 0

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