INT195531

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 5.02
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rel) cytoplasm (Rel)
Anatomy Link Frequency
neurons 3
astrocytes 1
Rel (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 120 100.00 Very High Very High Very High
chemokine 21 100.00 Very High Very High Very High
opiate 18 100.00 Very High Very High Very High
Central nervous system 54 99.68 Very High Very High Very High
agonist 44 96.76 Very High Very High Very High
Inflammation 123 96.00 Very High Very High Very High
Opioid 4 94.48 High High
Morphine 78 92.48 High High
Spinal cord 22 91.28 High High
Dorsal horn 24 90.52 High High
Disease Link Frequency Relevance Heat
Disease 62 97.64 Very High Very High Very High
INFLAMMATION 145 96.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 32 93.76 High High
Cholesteatoma 120 93.40 High High
Cancer 92 92.12 High High
Hyperplasia 14 89.60 High High
Hepatocellular Cancer 96 86.24 High High
Viral Meningitis 2 84.28 Quite High
Metastasis 8 77.44 Quite High
Pain 29 76.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Not surprisingly, overexpression of normal Rel proteins promotes oncogenic transformation.
Gene_expression (overexpression) of Rel
1) Confidence 0.75 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.55 Pain Relevance 0.03
For example, mice overexpressing Rel/p65 NF-?
Gene_expression (/) of Rel
2) Confidence 0.65 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.63 Pain Relevance 0.06
For example, mice overexpressing Rel/p65 NF-?
Gene_expression (overexpressing) of Rel
3) Confidence 0.65 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.63 Pain Relevance 0.06
B family of transcription factors is comprised of the subunits p65 (RelA), cRel, RelB, p50 (NF-?
Gene_expression (comprised) of cRel
4) Confidence 0.16 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.63 Pain Relevance 0.07
B family member c-Rel, which is not activated by acetylation, is expressed in cultured DRG neurons (Fig 2B).
Gene_expression (expressed) of c-Rel in neurons
5) Confidence 0.15 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0.36 Pain Relevance 0.60
B1, c-Rel, RelB, and p52/NF-?
Gene_expression (/) of c-Rel
6) Confidence 0.13 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.24 Pain Relevance 0.21
RelB, c-Rel, p50, p52) are widely expressed in the CNS [94] and activated in a
Gene_expression (expressed) of c-Rel associated with central nervous system
7) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 0.49 Pain Relevance 0.41
Expression of p65/Rel-A and c-Rel in DRG cultures
Gene_expression (Expression) of c-Rel
8) Confidence 0.11 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0 Pain Relevance 0.09
This evidence combined with the expression of p65/RelA and c-Rel in DRG neurons indicated that expression of mGlu2 and mGlu3 is endogenously regulated by the NF-?
Gene_expression (expression) of c-Rel in neurons
9) Confidence 0.11 Published 2006 Journal Mol Pain Section Abstract Doc Link PMC1550235 Disease Relevance 0.07 Pain Relevance 0.28
We examined the expression of p65/Rel-A and c-Rel proteins by immunocytochemistry, and found that both proteins were expressed by cultured mouse DRG neurons.
Spec (examined) Gene_expression (expression) of c-Rel in neurons
10) Confidence 0.11 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0 Pain Relevance 0.08
B) subunit, c-Rel, was a likely candidate for Tat or Tat plus opiate-induced increases in cytokine and chemokine production by astrocytes.
Gene_expression (production) of c-Rel in astrocytes associated with chemokine, opiate and cytokine
11) Confidence 0.09 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2605563 Disease Relevance 0.42 Pain Relevance 0.84

General Comments

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