INT195535

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 3.37
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm3) plasma membrane (Grm3) intracellular (Grm3)
signal transducer activity (Grm3)
Anatomy Link Frequency
neurons 3
striatum 1
astrocytes 1
microglia 1
Grm3 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 25 100.00 Very High Very High Very High
antinociception 1 99.60 Very High Very High Very High
Pain 5 98.52 Very High Very High Very High
analgesia 10 97.72 Very High Very High Very High
cytokine 4 96.68 Very High Very High Very High
Glutamate 36 96.04 Very High Very High Very High
agonist 171 94.28 High High
Neuropathic pain 5 84.80 Quite High
Potency 12 83.60 Quite High
antagonist 61 82.68 Quite High
Disease Link Frequency Relevance Heat
Pain 7 98.52 Very High Very High Very High
Death 15 97.36 Very High Very High Very High
Parkinsonian Disorders 42 96.92 Very High Very High Very High
Parkinson's Disease 249 96.04 Very High Very High Very High
Toxicity 66 93.96 High High
INFLAMMATION 23 86.40 High High
Disease 102 86.12 High High
Neuropathic Pain 5 84.80 Quite High
Sleep Disorders 12 81.04 Quite High
Ataxia 12 80.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using pure cultures of striatal neurons we could
               establish that activation of mGlu3 receptors enhanced GDNF production by stimulating
               the MAPK and the PI-3-K pathways. 
Positive_regulation (activation) of mGlu3 in neurons
1) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0 Pain Relevance 0.07
Activation of mGlu3 Receptors Stimulates the Production of GDNF in
                   Striatal Neurons

Metabotropic glutamate (mGlu) receptors have been considered potential targets

                   for the therapy of experimental parkinsonism. 
Positive_regulation (Activation) of mGlu3 in Neurons associated with glutamate and parkinsonian disorders
2) Confidence 0.16 Published 2009 Journal PLoS ONE Section Title Doc Link PMC2719807 Disease Relevance 0.25 Pain Relevance 0.21
Interestingly, LY379268 lost its protective activity in the implantation side,
               lending credit to the hypothesis that mGlu3 receptor activation protects
                   via an increase in striatal GDNF levels. 
Positive_regulation (activation) of mGlu3
3) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.60 Pain Relevance 0.03
Pharmacological activation of mGlu3 receptors enhances GDNF formation in
                   the striatum
Positive_regulation (activation) of mGlu3 in striatum
4) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.55 Pain Relevance 0.09
Activation of mGlu3 receptors present in
               astrocytes enhances the production of TGF-?
Positive_regulation (Activation) of mGlu3 in astrocytes
5) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.54 Pain Relevance 0.19
Activation of mGlu3 receptors enhances GDNF levels in cultured striatal
                   neurons (but not in astrocytes) via the activation of the MAP kinase and the
                   phosphatidylinositol-3-kinase pathways
Positive_regulation (Activation) of mGlu3 in neurons
6) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.30 Pain Relevance 0
Activation of group II metabotropic glutamate receptors (mGlu2 and mGlu3) induces antinociception in several pain models in rodents [1-5].
Positive_regulation (Activation) of mGlu3 associated with pain, antinociception and glutamate receptor
7) Confidence 0.06 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0.31 Pain Relevance 0.72
Interestingly, in vitro, activation of mGluR3 expressed in microglia inhibits microglial activation and secretion of neurotoxic cytokines [42, 43].
Positive_regulation (activation) of mGluR3 in microglia associated with cytokine
8) Confidence 0.02 Published 2010 Journal Parkinson's Disease Section Body Doc Link PMC2951138 Disease Relevance 0.25 Pain Relevance 0.17
Again, these data are consistent with divergent roles of mGluR2 and 3 in vivo [15] and may certainly also contribute to the modest neuroprotective effects of 2R,4R-APDC in vivo by counterbalancing beneficial effects of mGluR3 activation.
Positive_regulation (activation) of mGluR3
9) Confidence 0.02 Published 2010 Journal Parkinson's Disease Section Body Doc Link PMC2951138 Disease Relevance 0.18 Pain Relevance 0.09
mice, strongly suggesting that these in vivo neuroprotective effects are dependent on the activation of mGluR3 [15].
Positive_regulation (activation) of mGluR3
10) Confidence 0.01 Published 2010 Journal Parkinson's Disease Section Body Doc Link PMC2951138 Disease Relevance 0.39 Pain Relevance 0.10

General Comments

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