INT195541

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Context Info
Confidence 0.02
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.40
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm2) hydrolase activity, acting on glycosyl bonds (Lct) plasma membrane (Grm2)
intracellular (Grm2) signal transducer activity (Grm2)
Anatomy Link Frequency
spinal cord 2
dorsal horn 2
Lct (Mus musculus)
Grm2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 24 99.52 Very High Very High Very High
Spinal cord 16 98.76 Very High Very High Very High
analgesia 28 98.68 Very High Very High Very High
antagonist 4 97.00 Very High Very High Very High
Neuropathic pain 20 88.80 High High
Pain 20 87.16 High High
antinociception 4 71.36 Quite High
Glutamate receptor 28 69.68 Quite High
Analgesic 20 60.24 Quite High
Inflammation 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 20 88.80 High High
Pain 28 87.16 High High
INFLAMMATION 20 5.00 Very Low Very Low Very Low
Nervous System Injury 8 5.00 Very Low Very Low Very Low
Inflammatory Pain 4 5.00 Very Low Very Low Very Low
Syndrome 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, LAC selectively enhances the expression of mGlu2 receptors and has no effect on the expression of mGlu3 receptors [10,15], although these two receptor subtypes are highly homologous and share similar functions in the CNS [16].
LAC Positive_regulation (enhances) of Gene_expression (expression) of mGlu2
1) Confidence 0.02 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0.40 Pain Relevance 0.94
These results confirm our in vivo studies in which we showed that LAC selectively induces mGlu2 mRNA expression in the rat dorsal horn of the spinal cord and in the DRG without affecting mGlu3 levels [10].
LAC Positive_regulation (induces) of Gene_expression (expression) of mGlu2 mRNA in dorsal horn associated with dorsal horn and spinal cord
2) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0 Pain Relevance 0.10
LAC, behaving as donor of acetyl groups, could induce mGlu2 mRNA expression by promoting the acetylation of p65/Rel-A.
LAC Positive_regulation (induce) of Gene_expression (expression) of mGlu2 mRNA
3) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0 Pain Relevance 0.14
mGlu2 mRNA expression has been shown to be increased by LAC both in the dorsal horn of the rat spinal cord and in the DRG (Chiechio et al., 2002, and this study).
LAC Positive_regulation (increased) of Gene_expression (expression) of mGlu2 mRNA in spinal cord associated with dorsal horn and spinal cord
4) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0 Pain Relevance 0.10

General Comments

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