INT195576

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Context Info
Confidence 0.06
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.79
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Myo1f)
Anatomy Link Frequency
sarcomeres 1
endothelial cell 1
filaments 1
Myo1f (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 2 96.16 Very High Very High Very High
Inflammatory mediators 4 84.28 Quite High
imagery 20 67.12 Quite High
ketamine 6 48.24 Quite Low
Inflammatory response 3 43.08 Quite Low
Inflammation 11 33.80 Quite Low
Bioavailability 2 25.80 Quite Low
alcohol 4 19.12 Low Low
anesthesia 13 15.44 Low Low
Serotonin 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acidosis 1 99.38 Very High Very High Very High
Fatigue 17 97.84 Very High Very High Very High
Stress 17 96.16 Very High Very High Very High
Adhesions 39 88.28 High High
INFLAMMATION 18 83.88 Quite High
Pressure And Volume Under Development 2 81.64 Quite High
Targeted Disruption 57 78.48 Quite High
Sepsis 37 78.44 Quite High
Injury 5 75.12 Quite High
Cancer 1 74.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Examination of the P myosin preparations with immunofluorescence microscopy confirmed the presence of fragments of sarcomeres staining positively for MyHCemb and ?
myosin Binding (preparations) of in sarcomeres
1) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844429 Disease Relevance 0 Pain Relevance 0
Myosin preparations conventionally employ high ionic strength extraction buffers to solubilize fibrillar myosin.
myosin Binding (solubilize) of
2) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844429 Disease Relevance 0 Pain Relevance 0
We speculate that Rab27 proteins recruit a Rab-and-Myosin linker effector such as Melanophilin or Myrip, which will then recruit an unconventional myosin.
myosin Binding (recruit) of
3) Confidence 0.04 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.27 Pain Relevance 0.03
To understand the basis for these capsid movements, we sought to find a myosin motor that associates with the capsids.
myosin Binding (associates) of
4) Confidence 0.01 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1550268 Disease Relevance 0 Pain Relevance 0
As a first step toward testing these ideas, it will be important to understand how viral capsids interact with nuclear actin filaments by identifying viral proteins that interact with actin and/or myosin.


myosin Binding (interact) of in filaments
5) Confidence 0.01 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1550268 Disease Relevance 0.64 Pain Relevance 0
Both endothelial cell contraction, which involves actin-myosin interaction and changes in intracellular calcium, and passive cellular retraction, which probably involves protein kinase C phosphorylation and actin linking at intercellular tight junctions [24], can alter endothelial shape and can result in increased leakage.
actin-myosin Binding (interaction) of in endothelial cell associated with kinase c
6) Confidence 0.01 Published 2007 Journal Crit Care Section Body Doc Link PMC2246221 Disease Relevance 1.00 Pain Relevance 0.18
Acidosis and increased Pi each inhibit actin-myosin interaction, precipitating contractile failure, and this type of fatigue is also associated with oxidative stress (51).
actin-myosin Binding (interaction) of associated with stress, acidosis and fatigue
7) Confidence 0.00 Published 2010 Journal American Journal of Physiology - Regulatory, Integrative and Comparative Physiology Section Body Doc Link PMC2806206 Disease Relevance 0.88 Pain Relevance 0

General Comments

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