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Context Info
Confidence 0.08
First Reported 1991
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.09
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Alpk1) kinase activity (Alpk1) cellular_component (Alpk1)
biological_process (Alpk1)
Anatomy Link Frequency
LAK cells 1
T cells 1
Alpk1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1 88.08 High High
palliative 1 87.20 High High
headache 1 51.76 Quite High
Thoracotomy 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Metastasis 11 99.72 Very High Very High Very High
Apoptosis 1 97.52 Very High Very High Very High
Renal Cancer 4 89.56 High High
Pancreatic Cancer 2 75.00 Quite High
Immunotherapy Of Cancer 1 75.00 Quite High
Adenocarcinoma 1 65.64 Quite High
Headache 1 51.76 Quite High
Chills 1 50.32 Quite High
Fever 2 49.68 Quite Low
Leukocytosis 1 48.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LAK cells, generated by incubation in 2 units/ml of IL 2 for 3-4 days, were intravenously administered once or twice a week.
Gene_expression (generated) of LAK in LAK cells
1) Confidence 0.08 Published 1991 Journal Nippon Hinyokika Gakkai Zasshi Section Abstract Doc Link 2072602 Disease Relevance 0.65 Pain Relevance 0.05
Significant differences occurred in several parameters between pretreatment patient and control values: fewer CD8+ cells and increased apoptosis-prone CD3+/CD95+ lymphocytes, higher frequency of MDC, reduced allostimulatory activity by ex vivo-generated DC, depressed LAK activity, elevated IL-10 and IL-12p40 production; impaired IL-12p70 and IFN-gamma production by stimulated PBMC and T cells.
Gene_expression (production) of LAK in T cells associated with apoptosis
2) Confidence 0.04 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19424589 Disease Relevance 0.44 Pain Relevance 0.13

General Comments

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