INT19563

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1991
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.68
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CHRM3) signal transduction (CHRM3) protein modification process (CHRM3)
small molecule metabolic process (CHRM3) plasma membrane (CHRM3) signal transducer activity (CHRM3)
Anatomy Link Frequency
smooth muscle cells 3
smooth muscle 1
cornea 1
CHRM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 47 96.20 Very High Very High Very High
bradykinin 18 89.72 High High
Inflammatory mediators 16 87.84 High High
anesthesia 3 73.08 Quite High
epidural 1 72.64 Quite High
Inflammation 101 68.00 Quite High
agonist 181 64.88 Quite High
cytokine 20 21.28 Low Low
Neurotransmitter 6 18.88 Low Low
Central nervous system 2 16.60 Low Low
Disease Link Frequency Relevance Heat
Airway Obstruction 6 99.54 Very High Very High Very High
Pulmonary Disease 364 98.72 Very High Very High Very High
Occupational Lung Diseases 15 98.36 Very High Very High Very High
Asthma 137 97.96 Very High Very High Very High
Congenital Anomalies 2 94.52 High High
INFLAMMATION 120 87.44 High High
Shock 7 75.00 Quite High
Targeted Disruption 4 74.64 Quite High
Myopia 114 74.60 Quite High
Disease 58 74.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The levels of NAG, beta 2MG and urinary protein in the HM3 series were higher than those of the modified HM3 series.
Gene_expression (levels) of HM3
1) Confidence 0.58 Published 1991 Journal Nippon Hinyokika Gakkai Zasshi Section Abstract Doc Link 2072608 Disease Relevance 0.27 Pain Relevance 0.11
Figure 1 shows the amplification products for CHRM1 (365 bp), CHRM2 (197 bp), CHRM3 (325 bp), CHRM4 (394 bp), and CHRM5 (173 bp) receptor genes in the different tissues investigated.
Spec (investigated) Gene_expression (products) of CHRM3
2) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2649308 Disease Relevance 0.07 Pain Relevance 0
This is evidenced by the fact that the CHRM1, CHRM3, and CHRM4 transcripts were not detected in the Socci et al. [59,60] study and the M1 and M3 receptors were not found in the human cornea.
Neg (not) Gene_expression (detected) of CHRM3 in cornea
3) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2649308 Disease Relevance 0.07 Pain Relevance 0.03
Specific changes in ASM cells relevant to GPCR signaling that are known to occur in culture include a rapid and progressive decrease in the expression of Gq-coupled receptors such as the m3 muscarinic acetylcholine receptor (m3 mAChR) [21] and the cysteinyl leukotriene type 1 receptor (CLT1R; Stuart Hirst, personal communication).
Gene_expression (expression) of m3 muscarinic acetylcholine receptor
4) Confidence 0.09 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0 Pain Relevance 0.03
Although the altered expression of the postjunctional muscarinic M3 receptor on airway smooth muscle cells is not a feature of airway hyperreactivity to inhaled methacholine, changes in downstream signaling from these receptors may be a contributing factor [16].
Gene_expression (expression) of M3 receptor in smooth muscle cells associated with asthma
5) Confidence 0.05 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.98 Pain Relevance 0.06
Despite its lower expression levels, the Gq coupled muscarinic M3 receptor is the primary subtype responsible for bronchial and tracheal smooth muscle contraction; this is evident from the functional affinities of a variety of subtype selective antagonists in airway tissues from diverse species, including humans [8-11] (Table 1).
Gene_expression (expression) of M3 receptor in smooth muscle associated with antagonist
6) Confidence 0.04 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.56 Pain Relevance 0.08
Their effect on airway obstruction is mainly due both to M3 muscarinic receptor antagonism in the airway smooth muscle cells, with consequent bronchodilation, and to M3 muscarinic receptor antagonism in the cells of the submucosal glands, with a reduction in the basal and stimulated cholinergic parasympathetic activity with consequent reduction in airway obstruction.
Gene_expression (antagonism) of M3 muscarinic receptor in smooth muscle cells associated with airway obstruction
7) Confidence 0.04 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707800 Disease Relevance 0.33 Pain Relevance 0.19
Their effect on airway obstruction is mainly due both to M3 muscarinic receptor antagonism in the airway smooth muscle cells, with consequent bronchodilation, and to M3 muscarinic receptor antagonism in the cells of the submucosal glands, with a reduction in the basal and stimulated cholinergic parasympathetic activity with consequent reduction in airway obstruction.
Gene_expression (antagonism) of M3 muscarinic receptor in smooth muscle cells associated with airway obstruction
8) Confidence 0.04 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707800 Disease Relevance 0.39 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox