INT195668

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Context Info
Confidence 0.08
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.67
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F2, THBD) plasma membrane (F2, THBD) peptidase activity (F2)
extracellular region (F2) embryo development (THBD)
Anatomy Link Frequency
endothelial cell 3
F2 (Homo sapiens)
THBD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 590 99.08 Very High Very High Very High
cytokine 597 84.24 Quite High
Inflammatory response 41 38.32 Quite Low
cva 63 5.00 Very Low Very Low Very Low
imagery 14 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
depression 8 5.00 Very Low Very Low Very Low
addiction 8 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 637 99.08 Very High Very High Very High
Injury 428 97.30 Very High Very High Very High
Coagulation Disorder 66 97.10 Very High Very High Very High
Adhesions 48 93.76 High High
Hemorrhage 269 87.80 High High
Thrombophilia 7 86.92 High High
Necrosis 10 84.88 Quite High
Cancer 25 84.52 Quite High
Thrombosis 57 83.92 Quite High
Critical Illness 6 79.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This early coagulopathy of trauma is mainly found in patients with hypoperfusion (base deficit >6 mE/l) [8,245] and is characterised by an up-regulation of endothelial thrombomodulin, which forms complexes with thrombin [246].
thrombin Binding (forms) of thrombomodulin associated with coagulation disorder and injury
1) Confidence 0.08 Published 2010 Journal Crit Care Section Body Doc Link PMC2887168 Disease Relevance 0.95 Pain Relevance 0
This early coagulopathy of trauma is mainly found in patients with hypoperfusion (base deficit >6 mE/l) [8,245] and is characterised by an up-regulation of endothelial thrombomodulin, which forms complexes with thrombin [246].
thrombin Binding (complexes) of thrombomodulin associated with coagulation disorder and injury
2) Confidence 0.08 Published 2010 Journal Crit Care Section Body Doc Link PMC2887168 Disease Relevance 0.95 Pain Relevance 0
Protein C is activated to protein Ca 20,000 times faster than by thrombin alone through the interaction of thrombomodulin and thrombin on the endothelial cell surface (27).
thrombin Binding (interaction) of thrombomodulin in endothelial cell
3) Confidence 0.04 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816339 Disease Relevance 0.44 Pain Relevance 0
The zymogen PC is converted to an active serine protease activated protein C (APC) by thrombin bound to thrombomodulin on the endothelial surface [6].
thrombin Binding (bound) of thrombomodulin
4) Confidence 0.03 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 1.40 Pain Relevance 0.30
When bound to thrombomodulin, a thrombin receptor on the endothelial cell surface, thrombin activates protein C, which can degrade Factor VIIIa and Factor Va, essential cofactors in the activation of Factor X and prothrombin respectively [164].
thrombin Binding (bound) of thrombomodulin in endothelial cell
5) Confidence 0.01 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 0.42 Pain Relevance 0.24
Moreover, thrombin – thrombomodulin complex formation will be low in tissues where endothelial thrombomodulin is low.
thrombin Binding (formation) of thrombomodulin
6) Confidence 0.01 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 0.49 Pain Relevance 0.10
Moreover, thrombin – thrombomodulin complex formation will be low in tissues where endothelial thrombomodulin is low.
thrombin Binding (formation) of thrombomodulin
7) Confidence 0.01 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 0.49 Pain Relevance 0.10
When bound to thrombomodulin, a thrombin receptor on the endothelial cell surface, thrombin activates protein C, which can degrade Factor VIIIa and Factor Va, essential cofactors in the activation of Factor X and prothrombin respectively [164].
prothrombin Binding (bound) of thrombomodulin in endothelial cell
8) Confidence 0.01 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 0.54 Pain Relevance 0.24

General Comments

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