INT195679

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.43
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APC) chromosome organization (APC) cell adhesion (APC)
plasma membrane (APC) cytoskeleton (APC) nucleus (APC)
Anatomy Link Frequency
plasma 2
APC (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 6 51.20 Quite High
Inflammation 53 50.80 Quite High
metalloproteinase 12 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 113 100.00 Very High Very High Very High
Pancreatitis 89 100.00 Very High Very High Very High
Hepatocellular Cancer 55 99.84 Very High Very High Very High
Colorectal Cancer 95 99.44 Very High Very High Very High
Adenoma 12 97.68 Very High Very High Very High
Sepsis 18 97.34 Very High Very High Very High
Adenocarcinoma 4 97.24 Very High Very High Very High
Chromosomal Instability 4 93.60 High High
Cancer 187 93.52 High High
Colon Cancer 13 92.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that quantitative epigenetic changes are probably of clinical significance in hepatocarcinogenesis, but further post-transcriptional mechanisms must also be responsible for inactivation of the APC gene in HCC.
Positive_regulation (responsible) of Positive_regulation (inactivation) of APC gene associated with hepatocellular cancer and familial adenomatous polyposis
1) Confidence 0.50 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.78 Pain Relevance 0.05
Therefore, in good accordance with the study by Liaw and colleagues in adult septic patients [28], we assume that the lack of elevated free APC levels in the presence of activated coagulation in patients with AP in most cases reflected dysfunctional PC activation on the endothelium, or possibly enhanced inhibition of APC by plasma protease inhibitors.
Positive_regulation (enhanced) of Positive_regulation (elevated) of APC in plasma associated with pancreatitis
2) Confidence 0.47 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.70 Pain Relevance 0
In children with meningococceal sepsis, on the other hand, patients' ability to generate APC in response to thrombin did not seem to be grossly affected as infusion of PC resulted in elevated levels of APC, and significant correlations were observed between APC and thrombin markers at baseline [17].
Positive_regulation (resulted) of Positive_regulation (elevated) of APC associated with sepsis
3) Confidence 0.44 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.24 Pain Relevance 0
Like K-ras, APC mutation appears to be an early-genetic event during the progression from adenoma to adenocarcinoma, suggesting its potential for use as a screening biomarker.
Spec (appears) Positive_regulation (appears) of Positive_regulation (mutation) of APC associated with adenocarcinoma, adenoma and familial adenomatous polyposis
4) Confidence 0.42 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.42 Pain Relevance 0
Animals were randomly assigned to one of the four following groups: rabbits in the control (CTRL) group (n = 6) received normal saline; those in the LPS group (n = 6) received LPS alone; those in the LPS+aPC group (n = 6) received aPC (2 mg/kg) as a single bolus injection 1 hour after the LPS injection; and 4 rabbits received aPC alone 1 hour after saline injection in the same condition.
Positive_regulation (those) of Positive_regulation (group) of aPC
5) Confidence 0.34 Published 2006 Journal Crit Care Section Body Doc Link PMC1550919 Disease Relevance 0.20 Pain Relevance 0
The fzy-mediated APC/C activity is required for the degradation of securin during the onset of anaphase, while fzr-mediated APC/C activity is essential for the degradation of mitotic cyclins, fzy, and other substrates [38,39].


Positive_regulation (essential) of Positive_regulation (mediated) of APC
6) Confidence 0.05 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.09 Pain Relevance 0

General Comments

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