INT195681

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.90
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APC) chromosome organization (APC) cell adhesion (APC)
plasma membrane (APC) cytoskeleton (APC) nucleus (APC)
Anatomy Link Frequency
plasma 2
colon 2
vessels 2
APC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 26 39.48 Quite Low
cINOD 14 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 163 100.00 Very High Very High Very High
Familial Adenomatous Polyposis 64 100.00 Very High Very High Very High
Colon Cancer 23 99.86 Very High Very High Very High
Solid Tumor 1 99.16 Very High Very High Very High
Pancreatitis 45 98.30 Very High Very High Very High
Carcinoma 19 98.16 Very High Very High Very High
Adenoma 44 95.04 Very High Very High Very High
Colorectal Cancer 163 87.08 High High
Disease 34 86.44 High High
Apoptosis 29 78.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, in good accordance with the study by Liaw and colleagues in adult septic patients [28], we assume that the lack of elevated free APC levels in the presence of activated coagulation in patients with AP in most cases reflected dysfunctional PC activation on the endothelium, or possibly enhanced inhibition of APC by plasma protease inhibitors.
Positive_regulation (enhanced) of Negative_regulation (inhibition) of APC in plasma associated with pancreatitis
1) Confidence 0.47 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.70 Pain Relevance 0
Overexpression of SND1 in colon cancer cells caused down-regulation of APC and activation of the Wnt signaling pathway as a consequence, without altering APC mRNA levels.
Positive_regulation (caused) of Negative_regulation (regulation) of APC in colon associated with familial adenomatous polyposis and colon cancer
2) Confidence 0.39 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 0.99 Pain Relevance 0
However, allelic loss of APC has been shown to increase in frequency as there is progression towards carcinoma [69].
Positive_regulation (increase) of Negative_regulation (loss) of APC associated with familial adenomatous polyposis and carcinoma
3) Confidence 0.38 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.40 Pain Relevance 0
A recent study by Zhu et al. showed that loss of the APC tumor suppressor induced HDAC2 expression in solid tumors [125].
Positive_regulation (induced) of Negative_regulation (loss) of APC associated with cancer and solid tumor
4) Confidence 0.10 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.57 Pain Relevance 0
In the context of high-risk keratoplasty, preformed corneal vessels and an elevated number of corneal APC are linked to promoting a faster presentation of antigen and a faster stimulation of the alloresponse against a corneal graft [14,15].
Positive_regulation (elevated) of Negative_regulation (number) of APC in vessels
5) Confidence 0.03 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956665 Disease Relevance 0.23 Pain Relevance 0

General Comments

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