INT195705

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.54
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SERPINC1, SDC4) cytoskeletal protein binding (SDC4) extracellular space (SERPINC1)
plasma membrane (SERPINC1) biological_process (SDC4)
Anatomy Link Frequency
monocytes 1
thrombocytes 1
SERPINC1 (Homo sapiens)
SDC4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 15 88.32 High High
Kinase C 3 77.28 Quite High
Central nervous system 3 61.88 Quite High
chemokine 3 59.28 Quite High
Inflammation 69 45.60 Quite Low
Inflammatory stimuli 3 21.60 Low Low
adenocard 6 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
qutenza 3 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 3 97.72 Very High Very High Very High
Sepsis 84 97.00 Very High Very High Very High
Disseminated Intravascular Coagulation 111 92.44 High High
Thrombosis 6 91.64 High High
Targeted Disruption 3 86.96 High High
Adhesions 9 83.12 Quite High
Cv Unclassified Under Development 12 58.64 Quite High
Injury 21 46.80 Quite Low
INFLAMMATION 72 45.60 Quite Low
Disease 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antithrombin binds to syndecan-4 in monocytes and thrombocytes, activates various signal transduction pathways, and thereby influences the functional behaviour of both of these blood cell types, which are so important in DIC [36,37,53,69].
Antithrombin Binding (binds) of syndecan-4 in thrombocytes associated with disseminated intravascular coagulation
1) Confidence 0.07 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.65 Pain Relevance 0.07
This might be due to the fact that heparin competitively inhibits the binding of antithrombin to syndecan-4 or other HSPGs.
antithrombin Binding (binding) of syndecan-4
2) Confidence 0.07 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.24 Pain Relevance 0.08
Antithrombin binds to syndecan-4 in monocytes and thrombocytes, activates various signal transduction pathways, and thereby influences the functional behaviour of both of these blood cell types, which are so important in DIC [36,37,53,69].
Antithrombin Binding (binds) of syndecan-4 in monocytes associated with disseminated intravascular coagulation
3) Confidence 0.02 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.65 Pain Relevance 0.07

General Comments

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