INT195724

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Context Info
Confidence 0.28
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.99
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (SDC4) extracellular region (SDC4) biological_process (SDC4)
Anatomy Link Frequency
blood vessels 1
monocytes 1
lymphocytes 1
thrombocytes 1
epithelial cells 1
SDC4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 7 99.60 Very High Very High Very High
Inflammation 148 98.26 Very High Very High Very High
rheumatoid arthritis 117 96.64 Very High Very High Very High
Arthritis 83 96.36 Very High Very High Very High
cytokine 32 89.04 High High
agonist 26 81.96 Quite High
chemokine 29 81.52 Quite High
adenocard 8 76.00 Quite High
Kinase C 4 72.80 Quite High
Pain 3 26.80 Quite Low
Disease Link Frequency Relevance Heat
Osteoarthritis 42 99.48 Very High Very High Very High
Cancer 34 98.92 Very High Very High Very High
INFLAMMATION 162 98.26 Very High Very High Very High
Rheumatoid Arthritis 117 96.64 Very High Very High Very High
Seronegative Spondarthritis 72 96.36 Very High Very High Very High
Cv Unclassified Under Development 16 96.36 Very High Very High Very High
Wound Healing 4 93.84 High High
Injury 28 84.52 Quite High
Carcinoma 7 72.24 Quite High
Disseminated Intravascular Coagulation 148 68.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4) known to be important in cancer.
Gene_expression (expression) of SDC4 associated with cancer
1) Confidence 0.28 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2970545 Disease Relevance 0.45 Pain Relevance 0.21
Syndecan-4 is expressed by leucocytes, and moreover antithrombin can regulate the migratory behaviour on the cell surface of neutrophils, monocytes, lymphocytes and eosinophiles [36,38,43].
Gene_expression (expressed) of Syndecan-4 in lymphocytes
2) Confidence 0.12 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.37 Pain Relevance 0.05
It can be assumed that antithrombin is also able to exert specific anticoagulatory and anti-inflammatory effects in thrombocytes via analogous biochemical mechanisms because it is known that syndecan-4 is also expressed by thrombocytes and that antisyndecan-4 antibodies can influence thrombocyte aggregation [71].
Gene_expression (expressed) of syndecan-4 in thrombocytes associated with inflammation
3) Confidence 0.09 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.44 Pain Relevance 0.24
However, expression of syndecan-4, glypican-1 and glypican-3 was detected in the epidermis (fig 5B,D,F) and blood vessels of human skin, similar to that previously reported,8 providing a positive control for these antibodies.
Gene_expression (expression) of syndecan-4 in blood vessels
4) Confidence 0.07 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2563418 Disease Relevance 0.87 Pain Relevance 0.36
They are expressed in a cell-, tissue- and development-specific manner.1 Syndecan-1 and -4 have been shown in endothelial cells,3 however, syndecan-1 is mainly expressed on epithelial cells with syndecan-4 expression on many cell types.
Gene_expression (expression) of syndecan-4 in epithelial cells
5) Confidence 0.07 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2563418 Disease Relevance 0.23 Pain Relevance 0
Syndecan-4 immunoreactivity was negative in all synovia (fig 5A) apart from some weak staining in the lining layer of early RA and PsA (table 2).
Neg (negative) Gene_expression (negative) of Syndecan-4 associated with rheumatoid arthritis and arthritis
6) Confidence 0.06 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2563418 Disease Relevance 0.89 Pain Relevance 0.36
Syndecan-4 is expressed by leucocytes, and moreover antithrombin can regulate the migratory behaviour on the cell surface of neutrophils, monocytes, lymphocytes and eosinophiles [36,38,43].
Gene_expression (expressed) of Syndecan-4 in neutrophils
7) Confidence 0.04 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.37 Pain Relevance 0.05
Syndecan-4 is expressed by leucocytes, and moreover antithrombin can regulate the migratory behaviour on the cell surface of neutrophils, monocytes, lymphocytes and eosinophiles [36,38,43].
Gene_expression (expressed) of Syndecan-4 in monocytes
8) Confidence 0.04 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.37 Pain Relevance 0.05

General Comments

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