INT19575

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Context Info
Confidence 0.43
First Reported 1990
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 2.07
Pain Relevance 11.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat)
Anatomy Link Frequency
neuronal 4
band 4
retina 2
nerve 2
neurons 2
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 155 100.00 Very High Very High Very High
Dopamine 49 100.00 Very High Very High Very High
noradrenaline 4 100.00 Very High Very High Very High
Pain threshold 2 100.00 Very High Very High Very High
tetrodotoxin 8 99.84 Very High Very High Very High
agonist 17 99.70 Very High Very High Very High
Dorsal horn 5 99.68 Very High Very High Very High
Neuropathic pain 8 99.46 Very High Very High Very High
Serotonin 28 99.36 Very High Very High Very High
spinal-cord stimulation 13 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 5 100.00 Very High Very High Very High
Neuropathic Pain 9 99.46 Very High Very High Very High
Hyperalgesia 4 98.04 Very High Very High Very High
Nervous System Injury 2 97.92 Very High Very High Very High
Complex Regional Pain Syndromes 1 96.76 Very High Very High Very High
Retina Disease 1 85.60 High High
Schizophrenia 9 80.88 Quite High
Scotoma 43 77.76 Quite High
Diabetic Nephropathy 2 75.00 Quite High
Depression 13 61.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously we found postnatal binge-like ethanol exposure using an artificial-rearing method in the rat delayed developmental up-regulation of GABA(A) receptors (GABA(A)Rs) in both medial septum/diagonal band (MS/DB) and cerebellar Purkinje neurons.
Negative_regulation (delayed) of Positive_regulation (up-regulation) of GABA in band associated with gaba
1) Confidence 0.43 Published 2001 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 11557091 Disease Relevance 0 Pain Relevance 0.29
Previously we found postnatal binge-like ethanol exposure using an artificial-rearing method in the rat delayed developmental up-regulation of GABA(A) receptors (GABA(A)Rs) in both medial septum/diagonal band (MS/DB) and cerebellar Purkinje neurons.
Negative_regulation (delayed) of Positive_regulation (up-regulation) of GABA in band associated with gaba
2) Confidence 0.43 Published 2001 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 11557091 Disease Relevance 0 Pain Relevance 0.30
The experiments also demonstrate that daily administration (10 mg/kg, i.p.) of amitriptyline, a tricyclic antidepressant used for the treatment of neuropathic pain, for 1 week after surgery prevents the decline in thermal pain threshold, the increase in GABA(B2) gene expression, and development of increased GABA(B) receptor function in spinal cord resulting from nerve damage.
Negative_regulation (prevents) of Positive_regulation (increased) of GABA in nerve associated with gaba, pain threshold, nervous system injury, neuropathic pain, tricyclic antidepressant, endep and spinal cord
3) Confidence 0.40 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16293232 Disease Relevance 0.76 Pain Relevance 1.54
Drug-induced increases in GABA and dopamine release were reversed by addition of 1 microM tetrodotoxin to the perfusion medium.
Negative_regulation (reversed) of Positive_regulation (increases) of GABA associated with tetrodotoxin, dopamine and gaba
4) Confidence 0.38 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2073921 Disease Relevance 0 Pain Relevance 0.96
MK-801 treatment effectively abolished the increases in 5-HT, noradrenaline, glycine and GABA levels as well as preventing the development of hyperalgesia.
Negative_regulation (abolished) of Positive_regulation (increases) of GABA associated with hyperalgesia, gaba and noradrenaline
5) Confidence 0.35 Published 1996 Journal Brain Res. Section Abstract Doc Link 8864294 Disease Relevance 0.43 Pain Relevance 1.22
The mechanisms of action of SCS have only been partly elucidated and include suppression of the hyper-excitability of the Wide Dynamic Range neurons and a GABA increase in the dorsal horn.
Negative_regulation (suppression) of Positive_regulation (increase) of GABA in dorsal horn associated with gaba, dorsal horn and spinal-cord stimulation
6) Confidence 0.34 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19015001 Disease Relevance 0.49 Pain Relevance 1.03
However, tetrodotoxin (10 microM) abolished the veratridine-induced increase in both GABA and dopamine, demonstrating that Na(+)-dependent neuronal activity is involved in this release mechanism.
Negative_regulation (abolished) of Positive_regulation (increase) of GABA in neuronal associated with tetrodotoxin, dopamine and gaba
7) Confidence 0.34 Published 1994 Journal Neuroscience Section Abstract Doc Link 7936192 Disease Relevance 0 Pain Relevance 1.33
The GABA increase was attenuated by local administration of tetrodotoxin (TTX), indicating neuronal origin.
Negative_regulation (attenuated) of Positive_regulation (increase) of GABA in neuronal associated with tetrodotoxin and gaba
8) Confidence 0.33 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9332739 Disease Relevance 0 Pain Relevance 0.50
The second is likely to arise from axon collaterals of SNr neurons themselves and is facilitated by an increase in firing via postsynaptic, somatodendritic 5-HT2C receptor activation, but it is depressed by GABA(B) receptor activation.
Negative_regulation (depressed) of Positive_regulation (activation) of GABA in neurons associated with gaba
9) Confidence 0.32 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8922413 Disease Relevance 0.06 Pain Relevance 0.75
Systemic administration of the mixed D1/D2 dopamine receptor agonist apomorphine increased extracellular GABA levels in the prefrontal cortex, but did not increase levels of glycine; the apomorphine-elicited increase in GABA levels was blocked by tetrodotoxin infusion into the prefrontal cortex.
Negative_regulation (blocked) of Positive_regulation (increase) of GABA in prefrontal associated with tetrodotoxin, gaba, dopamine receptor and agonist
10) Confidence 0.20 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9536031 Disease Relevance 0 Pain Relevance 0.75
Similarly, the ability of local infusion of the D2 agonist quinpirole to enhance extracellular GABA levels was blocked by sulpiride but not by SCH 23390.
Negative_regulation (blocked) of Positive_regulation (enhance) of GABA associated with gaba and agonist
11) Confidence 0.20 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9536031 Disease Relevance 0.08 Pain Relevance 1.03
They also noted that the administration of prazosin in conjunction with 5,7-dihydroxytryptamine could block the increase in GABA, showing that modafinil increases cortical GABA through a norepinephrine mediated pathway.
Negative_regulation (block) of Positive_regulation (increase) of GABA associated with gaba
12) Confidence 0.14 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654794 Disease Relevance 0 Pain Relevance 0.67
Both treatments resulted in a significant alteration of autonomic activity, as evident from the reduced respiratory activity and marked changes (either decrease evoked by GABA or increase evoked by kynurenic acid) in blood pressure (Fig. 5A).
Negative_regulation (decrease) of Positive_regulation (increase) of GABA in respiratory associated with gaba
13) Confidence 0.04 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538935 Disease Relevance 0 Pain Relevance 0.50
VGB itself accumulates in the retina in significantly higher concentrations relative to other tissues, and is associated with accumulation of GABA in the retina.62 In the setting of VGB treatment, animal studies demonstrate decreased activity of glutamic acid decarboxylase and GABA transaminase activity, and accumulation of GABA in the retina.
Negative_regulation (decreased) of Positive_regulation (accumulation) of GABA in retina associated with gaba
14) Confidence 0.04 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2762367 Disease Relevance 0.24 Pain Relevance 0.20

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