INT19576

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Context Info
Confidence 0.42
First Reported 1984
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.02
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tspo) aging (Tspo) response to stress (Tspo)
Anatomy Link Frequency
cingulate cortex 1
body 1
Tspo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 6 99.96 Very High Very High Very High
Morphine 10 98.88 Very High Very High Very High
Clonidine 2 97.68 Very High Very High Very High
gABA 3 94.08 High High
opiate 2 92.44 High High
narcan 1 88.92 High High
Intracerebroventricular 1 86.12 High High
GABAergic 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Death 2 99.74 Very High Very High Very High
Convulsion 2 99.54 Very High Very High Very High
Hypothermia 2 99.36 Very High Very High Very High
Stress 3 99.16 Very High Very High Very High
Hypoxia 3 99.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hypoxic stress-induced convulsion and death: protective effect of alpha 2-adrenoceptor and benzodiazepine receptor agonists and Ro 5-4864.
Negative_regulation (effect) of benzodiazepine receptor associated with stress, convulsion, hypoxia, agonist and death
1) Confidence 0.42 Published 1988 Journal Arch Int Pharmacodyn Ther Section Title Doc Link 2899423 Disease Relevance 0.85 Pain Relevance 0.41
Passive morphine infusion resulted in increases in muscarinic cholinergic receptor densities in the pyriform cortex and in decreases in the cingulate cortex while benzodiazepine receptor densities were decreased in both the hippocampal formation and entorhinal-subicular cortex compared to littermates receiving passive infusions of vehicle.
Negative_regulation (decreased) of benzodiazepine receptor in cingulate cortex associated with morphine
2) Confidence 0.40 Published 1984 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6324243 Disease Relevance 0 Pain Relevance 0.58
Flumazenil, a benzodiazepine receptor blocker, potentiated the action of morphine on body temperature.
Negative_regulation (blocker) of benzodiazepine receptor in body associated with morphine
3) Confidence 0.35 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2073923 Disease Relevance 0.17 Pain Relevance 0.77

General Comments

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