INT195773

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.78
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cd74, Mif) isomerase activity (Mif) Golgi apparatus (Cd74)
endoplasmic reticulum (Cd74) protein complex assembly (Cd74) vacuole (Cd74)
Anatomy Link Frequency
Macrophage 1
Cd74 (Mus musculus)
Mif (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 3 97.36 Very High Very High Very High
cytokine 25 96.60 Very High Very High Very High
Inflammation 55 96.20 Very High Very High Very High
Inflammatory mediators 5 94.20 High High
Inflammatory stimuli 1 76.72 Quite High
ischemia 1 73.96 Quite High
Inflammatory response 11 59.36 Quite High
dexamethasone 2 25.84 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammatory marker 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 76 96.20 Very High Very High Very High
Cancer 83 92.40 High High
Targeted Disruption 2 92.12 High High
Apoptosis 7 90.88 High High
Skin Cancer 2 89.12 High High
Reperfusion Injury 1 74.72 Quite High
Cv Unclassified Under Development 2 73.96 Quite High
Injury 8 73.00 Quite High
Breast Cancer 8 69.44 Quite High
Postoperative Complications 3 66.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While binding of MIF to CD74 and JAB1 was not significantly reduced, the mutation eliminated MIF enzymatic activity and intriguingly impaired specific MIF biological activity.
CD74 Binding (binding) of MIF
1) Confidence 0.25 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 0.78 Pain Relevance 0.04
While binding of MIF to CD74 and JAB1 was not significantly reduced, the mutation eliminated MIF enzymatic activity and intriguingly impaired specific MIF biological activity.
CD74 Binding (binding) of MIF
2) Confidence 0.25 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 0.85 Pain Relevance 0.04
Macrophage migration inhibitory factor (MIF) has been considered a central mediator of the innate immune response as a natural ligand of CD74 and has been implicated in cellular signaling and activation [6].
CD74 Binding (ligand) of migration inhibitory factor in Macrophage
3) Confidence 0.01 Published 2006 Journal Crit Care Section Body Doc Link PMC1550915 Disease Relevance 1.16 Pain Relevance 0.47

General Comments

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