INT195778

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Context Info
Confidence 0.19
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.78
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APC) chromosome organization (APC) cell adhesion (APC)
plasma membrane (APC) cytoskeleton (APC) nucleus (APC)
Anatomy Link Frequency
monocyte 1
APC (Homo sapiens)
PROCR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 59 98.44 Very High Very High Very High
cytokine 7 97.44 Very High Very High Very High
cva 6 89.64 High High
agonist 24 37.68 Quite Low
addiction 6 8.48 Low Low
anesthesia 7 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 58 98.44 Very High Very High Very High
Hemorrhage 6 98.12 Very High Very High Very High
Apoptosis 37 95.80 Very High Very High Very High
Pressure And Volume Under Development 6 90.40 High High
Cv General 3 Under Development 6 89.64 High High
Cv General 2 Under Development 72 86.88 High High
Sepsis 31 84.64 Quite High
Lung Injury 16 84.28 Quite High
Increased Venous Pressure Under Development 12 83.68 Quite High
Injury 91 82.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been suggested that, by binding to endothelial APC receptor (EPCR) and to protease activated receptor-1 (PAR-1), APC initiates cytoprotective reactions, gene expression profile alterations, and anti-inflammatory and anti-apoptotic effects [8-11].
APC Binding (binding) of EPCR associated with inflammation and apoptosis
1) Confidence 0.19 Published 2008 Journal Crit Care Section Body Doc Link PMC2646309 Disease Relevance 1.50 Pain Relevance 0.05
A recent study reports that aPC binding to EPCR is a prerequisite to its action on mortality [25].
aPC Binding (binding) of EPCR
2) Confidence 0.07 Published 2006 Journal Crit Care Section Body Doc Link PMC1550919 Disease Relevance 0.46 Pain Relevance 0.20
When aPC binds to EPCR, it activates a signaling pathway leading to inhibition of NF-?
aPC Binding (binds) of EPCR
3) Confidence 0.07 Published 2006 Journal Crit Care Section Body Doc Link PMC1550919 Disease Relevance 0.48 Pain Relevance 0.21
This could be caused by the lack of binding of aPC to EPCR, explaining its lack of effect on the NF-?
aPC Binding (binding) of EPCR
4) Confidence 0.05 Published 2006 Journal Crit Care Section Body Doc Link PMC1550919 Disease Relevance 0.51 Pain Relevance 0.05
This could result, at least in part, in a modified endothelial aPC signaling pathway due to EPCR dysfunction [15] or abnormal binding of aPC to EPCR.
aPC Binding (binding) of EPCR
5) Confidence 0.05 Published 2006 Journal Crit Care Section Body Doc Link PMC1550919 Disease Relevance 0.13 Pain Relevance 0
This could result, at least in part, in a modified endothelial aPC signaling pathway due to EPCR dysfunction [15] or abnormal binding of aPC to EPCR.
aPC Binding (binding) of EPCR
6) Confidence 0.05 Published 2006 Journal Crit Care Section Body Doc Link PMC1550919 Disease Relevance 0.13 Pain Relevance 0
Inadequate binding of aPC to EPCR could explain the absence of the anti-inflammatory effect and be responsible for the persistence of monocyte TF expression.
aPC Binding (binding) of EPCR in monocyte associated with inflammation
7) Confidence 0.05 Published 2006 Journal Crit Care Section Body Doc Link PMC1550919 Disease Relevance 0.57 Pain Relevance 0.22

General Comments

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