INT19578

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Context Info
Confidence 0.42
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 7.71
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (F13A1) transferase activity, transferring acyl groups (F13A1) cytoplasm (F13A1)
Anatomy Link Frequency
skin 2
F13A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 6 99.92 Very High Very High Very High
antagonist 5 98.70 Very High Very High Very High
headache 4 96.28 Very High Very High Very High
Angina 7 94.24 High High
cva 14 91.08 High High
spinal inflammation 1 90.12 High High
Piles 10 81.08 Quite High
imagery 1 71.52 Quite High
corticosteroid 1 11.20 Low Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 15 99.58 Very High Very High Very High
Purpura 25 99.52 Very High Very High Very High
Fistula 65 99.38 Very High Very High Very High
Hemorrhage 4 99.38 Very High Very High Very High
Acute Coronary Syndrome 7 98.44 Very High Very High Very High
Erythema 1 97.66 Very High Very High Very High
Arthralgia 2 97.08 Very High Very High Very High
Thrombosis 3 96.84 Very High Very High Very High
Myalgia 1 96.64 Very High Very High Very High
Cardiovascular Disease 1 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Management of an extrasphincteric fistula in an HIV-positive patient by using fibrin glue: a case report with tips and tricks

Background

Negative_regulation (using) of Gene_expression (glue) of fibrin associated with fistula and acquired immune deficiency syndrome or hiv infection
1) Confidence 0.42 Published 2010 Journal BMC Gastroenterol Section Title Doc Link PMC2829488 Disease Relevance 1.45 Pain Relevance 0.04
The increased risk of bleeding in HSP has been attributed to reduced levels of factor XIII [4] and prothrombin [5].
Negative_regulation (reduced) of Gene_expression (levels) of factor XIII associated with purpura and hemorrhage
2) Confidence 0.07 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2430708 Disease Relevance 1.50 Pain Relevance 0.19
Dermal matrices and fibrin glue
Negative_regulation (matrices) of Gene_expression (glue) of fibrin
3) Confidence 0.04 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501115 Disease Relevance 0.71 Pain Relevance 0
Skin lesions revealed superficial ulceration, purpura, atrophie blanche, and reticulate erythema on the lower extremities, and a skin biopsy showed a minimal dermal perivascular lymphocytic infiltrate with marked fibrin thrombi and fibrin deposits along luminal vessel walls, consistent with features of livedoid vasculopathy.
Negative_regulation (deposits) of Gene_expression (thrombi) of fibrin in skin associated with purpura and erythema
4) Confidence 0.04 Published 2009 Journal Am J Dermatopathol Section Abstract Doc Link 19384073 Disease Relevance 0.77 Pain Relevance 0.12
Mildly elevated levels of fibrin split products were seen after TNF treatment in 5/13 evaluable patients and one ineligible patient.
Negative_regulation (levels) of Gene_expression (products) of fibrin
5) Confidence 0.03 Published 1990 Journal J Biol Response Mod Section Abstract Doc Link 2074444 Disease Relevance 1.48 Pain Relevance 0.10
UFH was combined with aspirin to suppress thrombin propagation and fibrin formation in patients presenting with acute coronary syndromes (ACS) or patients undergoing percutaneous coronary intervention (PCI).
Negative_regulation (suppress) of Gene_expression (propagation) of fibrin associated with aspirin and acute coronary syndrome
6) Confidence 0.01 Published 2007 Journal Rev Cardiovasc Med Section Abstract Doc Link 17917621 Disease Relevance 0.55 Pain Relevance 0.26
Historically, unfractionated heparin (UFH) has been combined with aspirin to suppress thrombin propagation and fibrin formation; however, its effectiveness has been questioned in this setting.
Negative_regulation (suppress) of Gene_expression (propagation) of fibrin associated with aspirin
7) Confidence 0.01 Published 2004 Journal Pharmacotherapy Section Abstract Doc Link 15334859 Disease Relevance 0.76 Pain Relevance 0.22
Since a PAR-1 antagonist is specific for the cellulalr actions of thrombin, and does not interfere with fibrin generation, it is expected to have less bleeding liability than the currently available treatments.
Neg (not) Negative_regulation (interfere) of Gene_expression (generation) of fibrin associated with antagonist and hemorrhage
8) Confidence 0.00 Published 2003 Journal Curr Top Med Chem Section Abstract Doc Link 12769712 Disease Relevance 0.48 Pain Relevance 0.30

General Comments

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